Personal profile
Research interests
My research group specializes in functional precision medicine, developing advanced in vitro and ex vivo models to enhance cancer therapy testing, rare disease treatments, and diagnostic technologies.
Pancreatic Cancer (PDAC)
Patient-derived PDAC-on-chip
Organ-on-chip systems
To evaluate drug toxicity and metabolism within physiologically relevant human tissue models
Acute Myeloid Leukemia (AML)
The role of tumor associated macrophage polarization in therapy resistance
Stem Cell Models for Rare Diseases
iPSC-based disease model for Calpainopathy (LGMD R1)
Aptamers in Diagnostics & Targeted Therapy
Applications in cancer detection and malaria diagnostics
Research interests
My research group specializes in functional precision medicine, developing advanced in vitro and ex vivo models to enhance cancer therapy testing, rare disease treatments, and diagnostic technologies.
Organ-on-chip systems
To evaluate drug toxicity and metabolism within physiologically relevant human tissue models
Acute Myeloid Leukemia (AML)
The role of tumor associated macrophage polarization in therapy resistance
Stem Cell Models for Rare Diseases
iPSC-based disease model for Calpainopathy (LGMD R1)
Aptamers in Diagnostics & Targeted Therapy
Applications in cancer detection and malaria diagnostics
OECD Fields of Science
- 3. Medical and Health Sciences
- 3.1 Basic Medicine
- 6.1 History and Archaeology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 4 Quality Education -
SDG 5 Gender Equality
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Collaborations and top research areas from the last five years
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Immune cell infiltration correlates with intestinal permeability, inflammation, and gastrointestinal symptoms in type 1 diabetes
Zalizko, P., Isaks, R., Pahirko, L., Fedulovs, A., Krustins, E., Nazarovs, J., Dubencovs, S., Salmenkari, H., Lehto, M., Jēkabsons, K., Riekstiņa, U., Groop, P. H., Sandholm, N. & Sokolovska, J., Mar 2026, In: Journal of Diabetes Investigation. 17, 3, p. 420-431 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Age-dependent changes in visceral adiposity are associated with decreased plasma levels of DHEA-S in sigma-1 receptor knockout male mice
Stelfa, G., Miteniece, A., Svalbe, B., Vavers, E., Makrecka-Kuka, M., Kupats, E., Kunrade, L., Parfejevs, V., Riekstina, U., Dambrova, M. & Zvejniece, L., 2025, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1870, 1, p. 1-12 159571.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Generation of induced pluripotent stem cell lines from three LGMD R1 patients carrying CAPN3 hypomorphic intronic variant c.1746-20C > G
Goluba, K., Parfejevs, V., Neimane, A., Tvoronovica, A., Lāce, B., Ghazvini, M., Iņaškina, I. & Riekstiņa, U., Sept 2025, In: Stem Cell Research. 87, p. 1-5 103803.Research output: Contribution to journal › Article › peer-review
Open Access -
Physical model of serum supplemented medium flow in organ-on-a-chip systems
Šints, V., Cīmurs, J., Birjukovs, M., Driķis, I., Goluba, K., Jēkabsons, K., Parfejevs, V., Riekstiņa, U., Mozoļevskis, G., Rimša, R. & Kitenbergs, G., Jun 2025, In: PLOS ONE. 20, 6 June, e0322069.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Characterisation of 'Plasmodium' spp. lactate dehydrogenase specific aptamer binding affinity and selectivity
Kunrade, L., Sproģe, L., Pleiko, K., Goluba, K., Parfejevs, V., Riekstiņa, U., Baldrich Rubio, E. & Eva Baldrich Rubio, 2024, In: Medicina (Kaunas). 60Research output: Contribution to journal › Meeting abstract › peer-review