A three dimensional model for the interaction of MSH with the melanocortin-1 receptor

Peteris Prusis; Per Anders Frändberg; Ruta Muceniece; Ivars Kalvinsh; Jarl E.S. Wikberg

doi:10.1006/bbrc.1995.1647

A three dimensional model for the interaction of MSH with the melanocortin-1 receptor

Peteris Prusis
, Per Anders Frändberg
, Ruta Muceniece
, Ivars Kalvinsh
, Jarl E.S. Wikberg^*

^*Corresponding author for this work

Uppsala University
Latvian Institute of Organic Synthesis
Wa Pharm

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

A model for the interaction of the melanocortin-1 (MC1) receptor with MSH peptide has been constructed. The model was built by homology modelling bacteriorhodopsin as template. A cyclic analogue of MSH could be docked into binding pocket located between transmembrane (TM) domains 2, 3 and 6 of the receptor. The most significant receptor to ligand interactions occur between D117 in peptide and D121 in TM3 with arginine in peptide. The model finds support from earlier mutagenesis data.

Original language	English
Pages (from-to)	205-210
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	210
Issue number	1
DOIs	https://doi.org/10.1006/bbrc.1995.1647
Publication status	Published - 1995
Externally published	Yes

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abstract = "A model for the interaction of the melanocortin-1 (MC1) receptor with MSH peptide has been constructed. The model was built by homology modelling bacteriorhodopsin as template. A cyclic analogue of MSH could be docked into binding pocket located between transmembrane (TM) domains 2, 3 and 6 of the receptor. The most significant receptor to ligand interactions occur between D117 in peptide and D121 in TM3 with arginine in peptide. The model finds support from earlier mutagenesis data.",

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AU - Wikberg, Jarl E.S.

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AB - A model for the interaction of the melanocortin-1 (MC1) receptor with MSH peptide has been constructed. The model was built by homology modelling bacteriorhodopsin as template. A cyclic analogue of MSH could be docked into binding pocket located between transmembrane (TM) domains 2, 3 and 6 of the receptor. The most significant receptor to ligand interactions occur between D117 in peptide and D121 in TM3 with arginine in peptide. The model finds support from earlier mutagenesis data.

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A three dimensional model for the interaction of MSH with the melanocortin-1 receptor

Abstract

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