Dysregulation of CDX1, CDX2 and SOX2 in patients with gastric cancer also affects the non-malignant mucosa

Jan Bornschein; Kinga Tóth; Michael Selgrad; Doerthe Kuester; Thomas Wex; Béla Molnár; Zsolt Tulassay; Peter Malfertheiner

doi:10.1136/jclinpath-2013-201448

Dysregulation of CDX1, CDX2 and SOX2 in patients with gastric cancer also affects the non-malignant mucosa

Jan Bornschein
, Kinga Tóth
, Michael Selgrad
, Doerthe Kuester
, Thomas Wex
, Béla Molnár
, Zsolt Tulassay
, Peter Malfertheiner^*

^*Corresponding author for this work

Otto von Guericke University Magdeburg
Semmelweis University
Center for Laboratory Medicine, Microbiology and Infectious Diseases
Hungarian Academy of Sciences

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The interplay between gastric and intestinal transcription factors has an important impact on gastric carcinogenesis. We compared the gene expression of CDX1, CDX2, SOX2 and related downstream genes in tumour and tumour surrounding gastric tissue of 48 gastric cancer patients with 30 healthy controls. There was no difference of gene expression of CDX1 and CDX2 between tumour or tumour-adjacent and tumourdistant mucosa, but both factors were significantly higher expressed in cancer patients compared with controls (p<0.01). SOX2 was downregulated in tumour tissue compared to controls, whereas tumour-adjacent and tumour-distant mucosa showed intermediate SOX2 expression. Laurén type and Helicobacter pylori infection had no significant impact on expression of the transcription factors. Expression of CDX1 and CDX2 was higher in the presence of intestinal metaplasia. The differential regulation of the gene expression of CDX1, CDX2 and SOX2 in patients with gastric cancer affects not only the tumour but also the non-neoplastic tumour-distant mucosa.

Original language	English
Pages (from-to)	819-822
Number of pages	4
Journal	Journal of Clinical Pathology
Volume	66
Issue number	9
DOIs	https://doi.org/10.1136/jclinpath-2013-201448
Publication status	Published - Sept 2013
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1136/jclinpath-2013-201448

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title = "Dysregulation of CDX1, CDX2 and SOX2 in patients with gastric cancer also affects the non-malignant mucosa",

abstract = "The interplay between gastric and intestinal transcription factors has an important impact on gastric carcinogenesis. We compared the gene expression of CDX1, CDX2, SOX2 and related downstream genes in tumour and tumour surrounding gastric tissue of 48 gastric cancer patients with 30 healthy controls. There was no difference of gene expression of CDX1 and CDX2 between tumour or tumour-adjacent and tumourdistant mucosa, but both factors were significantly higher expressed in cancer patients compared with controls (p<0.01). SOX2 was downregulated in tumour tissue compared to controls, whereas tumour-adjacent and tumour-distant mucosa showed intermediate SOX2 expression. Laur{\'e}n type and Helicobacter pylori infection had no significant impact on expression of the transcription factors. Expression of CDX1 and CDX2 was higher in the presence of intestinal metaplasia. The differential regulation of the gene expression of CDX1, CDX2 and SOX2 in patients with gastric cancer affects not only the tumour but also the non-neoplastic tumour-distant mucosa.",

author = "Jan Bornschein and Kinga T{\'o}th and Michael Selgrad and Doerthe Kuester and Thomas Wex and B{\'e}la Moln{\'a}r and Zsolt Tulassay and Peter Malfertheiner",

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doi = "10.1136/jclinpath-2013-201448",

language = "English",

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AU - Bornschein, Jan

AU - Tóth, Kinga

AU - Selgrad, Michael

AU - Kuester, Doerthe

AU - Wex, Thomas

AU - Molnár, Béla

AU - Tulassay, Zsolt

AU - Malfertheiner, Peter

PY - 2013/9

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N2 - The interplay between gastric and intestinal transcription factors has an important impact on gastric carcinogenesis. We compared the gene expression of CDX1, CDX2, SOX2 and related downstream genes in tumour and tumour surrounding gastric tissue of 48 gastric cancer patients with 30 healthy controls. There was no difference of gene expression of CDX1 and CDX2 between tumour or tumour-adjacent and tumourdistant mucosa, but both factors were significantly higher expressed in cancer patients compared with controls (p<0.01). SOX2 was downregulated in tumour tissue compared to controls, whereas tumour-adjacent and tumour-distant mucosa showed intermediate SOX2 expression. Laurén type and Helicobacter pylori infection had no significant impact on expression of the transcription factors. Expression of CDX1 and CDX2 was higher in the presence of intestinal metaplasia. The differential regulation of the gene expression of CDX1, CDX2 and SOX2 in patients with gastric cancer affects not only the tumour but also the non-neoplastic tumour-distant mucosa.

AB - The interplay between gastric and intestinal transcription factors has an important impact on gastric carcinogenesis. We compared the gene expression of CDX1, CDX2, SOX2 and related downstream genes in tumour and tumour surrounding gastric tissue of 48 gastric cancer patients with 30 healthy controls. There was no difference of gene expression of CDX1 and CDX2 between tumour or tumour-adjacent and tumourdistant mucosa, but both factors were significantly higher expressed in cancer patients compared with controls (p<0.01). SOX2 was downregulated in tumour tissue compared to controls, whereas tumour-adjacent and tumour-distant mucosa showed intermediate SOX2 expression. Laurén type and Helicobacter pylori infection had no significant impact on expression of the transcription factors. Expression of CDX1 and CDX2 was higher in the presence of intestinal metaplasia. The differential regulation of the gene expression of CDX1, CDX2 and SOX2 in patients with gastric cancer affects not only the tumour but also the non-neoplastic tumour-distant mucosa.

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SN - 0021-9746

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JO - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

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ER -

Dysregulation of CDX1, CDX2 and SOX2 in patients with gastric cancer also affects the non-malignant mucosa

Abstract

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