Effects of metabolic syndrome on arterial function in different age groups: The Advanced Approach to Arterial Stiffness study

Jirar Topouchian; Carlos Labat; Sylvie Gautier; Magnus Bäck; Apostolos Achimastos; Jacques Blacher; Marcin Cwynar; Alejandro De La Sierra; Denes Pall; Francesco Fantin; Katalin Farkas; Luis Garcia-Ortiz; Zoya Hakobyan; Piotr Jankowski; Ana Jelakovic; Zhanna Kobalava; Alexandra Konradi; Yulia Kotovskaya; Marina Kotsani; Irina Lazareva; Alexander Litvin; Viktor Milyagin; Iveta Mintale; Oscar Persson; Rafael Ramos; Anatoly Rogoza; Ligita Ryliskyte; Angelo Scuteri; Yuriy Sirenko; Georges Soulis; Nebojsa Tasic; Maryna Udovychenko; Saule Urazalina; Peter Wohlfahrt; Parounak Zelveian; Athanase Benetos; Roland Asmar

doi:10.1097/HJH.0000000000001631

Effects of metabolic syndrome on arterial function in different age groups: The Advanced Approach to Arterial Stiffness study

Jirar Topouchian
, Carlos Labat
, Sylvie Gautier
, Magnus Bäck
, Apostolos Achimastos
, Jacques Blacher
, Marcin Cwynar
, Alejandro De La Sierra
, Denes Pall
, Francesco Fantin
, Katalin Farkas
, Luis Garcia-Ortiz
, Zoya Hakobyan
, Piotr Jankowski
, Ana Jelakovic
, Zhanna Kobalava
, Alexandra Konradi
, Yulia Kotovskaya
, Marina Kotsani
, Irina Lazareva

Alexander Litvin, Viktor Milyagin, Iveta Mintale, Oscar Persson, Rafael Ramos, Anatoly Rogoza, Ligita Ryliskyte, Angelo Scuteri, Yuriy Sirenko, Georges Soulis, Nebojsa Tasic, Maryna Udovychenko, Saule Urazalina, Peter Wohlfahrt, Parounak Zelveian, Athanase Benetos^*, Roland Asmar

^*Corresponding author for this work

Université Paris Cité
Université de Lorraine
CHU de Nancy
Karolinska Institutet
National and Kapodistrian University of Athens
Jagiellonian University Medical College
University of Barcelona
University of Debrecen
University of Verona
Szent Imre University Teaching Hospital
Salamanca Institute for Biomedical Research
Universidad de Salamanca
Institute of Cardiology
University of Zagreb
People's Friendship University of Russia
Almazov Federal Medical Research Centre
Pirogov Russian National Research Medical University
Russian Clinical and Research Centre of Gerontology
Republican Scientific and Practical Center Cardiology
RAS - USSR Cardiology Research Center
Russian Ministry of Health
Paula Stradina Clinical University Hospital
Institut Universitari d'Investigació en Atenció Primària Jordi Gol
University of Girona
Girona Biomedical Research Institute
Vilnius University
University of Rome Tor Vergata
National Scientific Center M.D. Strazhesko Institute of Cardiology
Harokopio University
Cardiovascular Institute
National Academy of Medical Sciences of Ukraine
JSC "Research Institute of Cardiology and Internal Diseases"
Charles University
Foundation-Medical Research Institutes

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

Objective: The aim of the Advanced Approach to Arterial Stiffness study was to compare arterial stiffness measured simultaneously with two different methods in different age groups of middle-aged and older adults with or without metabolic syndrome (MetS). The specific effects of the different MetS components on arterial stiffness were also studied. Methods: This prospective, multicentre, international study included 2224 patients aged 40 years and older, 1664 with and 560 without MetS. Patients were enrolled in 32 centres from 18 European countries affiliated to the International Society of Vascular Health & Aging. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) and the carotid-femoral pulse wave velocity (CF-PWV) in four prespecified age groups: 40-49, 50-59, 60-74, 75-90 years. In this report, we present the baseline data of this study. Results: Both CF-PWV and CAVI increased with age, with a higher correlation coefficient for CAVI (comparison of coefficients P<0.001). Age-adjusted and sex-adjusted values of CF-PWV and CAVI were weakly intercorrelated (r²=0.06, P<0.001). Age-adjusted and sex-adjusted values for CF-PWV but not CAVI were higher in presence of MetS (CF-PWV: 9.57±0.06 vs. 8.65±0.10, P<0.001; CAVI: 8.34±0.03 vs. 8.29±0.04, P=0.40; mean±SEM; MetS vs. no MetS). The absence of an overall effect of MetS on CAVI was related to the heterogeneous effects of the components of MetS on this parameter: CAVI was positively associated with the high glycaemia and high blood pressure components, whereas lacked significant associations with the HDL and triglycerides components while exhibiting a negative association with the overweight component. In contrast, all five MetS components showed positive associations with CF-PWV. Conclusion: This large European multicentre study reveals a differential impact of MetS and age on CAVI and CF PWV and suggests that age may have a more pronounced effect on CAVI, whereas MetS increases CF-PWV but not CAVI. This important finding may be due to heterogeneous effects of MetS components on CAVI. The clinical significance of these original results will be assessed during the longitudinal phase of the study.

Original language	English
Pages (from-to)	824-833
Number of pages	10
Journal	Journal of Hypertension
Volume	36
Issue number	4
DOIs	https://doi.org/10.1097/HJH.0000000000001631
Publication status	Published - Apr 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Arterial tiffness
Cardio-ankle ascular index
Large artery
Metabolic syndrome
Pulse wave velocity
ging

Access to Document

10.1097/HJH.0000000000001631

Cite this

Topouchian, J., Labat, C., Gautier, S., Bäck, M., Achimastos, A., Blacher, J., Cwynar, M., De La Sierra, A., Pall, D., Fantin, F., Farkas, K., Garcia-Ortiz, L., Hakobyan, Z., Jankowski, P., Jelakovic, A., Kobalava, Z., Konradi, A., Kotovskaya, Y., Kotsani, M., ... Asmar, R. (2018). Effects of metabolic syndrome on arterial function in different age groups: The Advanced Approach to Arterial Stiffness study. Journal of Hypertension, 36(4), 824-833. https://doi.org/10.1097/HJH.0000000000001631

@article{0f0f11ab1d4745c091c33b27c73979e7,

title = "Effects of metabolic syndrome on arterial function in different age groups: The Advanced Approach to Arterial Stiffness study",

abstract = "Objective: The aim of the Advanced Approach to Arterial Stiffness study was to compare arterial stiffness measured simultaneously with two different methods in different age groups of middle-aged and older adults with or without metabolic syndrome (MetS). The specific effects of the different MetS components on arterial stiffness were also studied. Methods: This prospective, multicentre, international study included 2224 patients aged 40 years and older, 1664 with and 560 without MetS. Patients were enrolled in 32 centres from 18 European countries affiliated to the International Society of Vascular Health \& Aging. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) and the carotid-femoral pulse wave velocity (CF-PWV) in four prespecified age groups: 40-49, 50-59, 60-74, 75-90 years. In this report, we present the baseline data of this study. Results: Both CF-PWV and CAVI increased with age, with a higher correlation coefficient for CAVI (comparison of coefficients P<0.001). Age-adjusted and sex-adjusted values of CF-PWV and CAVI were weakly intercorrelated (r2=0.06, P<0.001). Age-adjusted and sex-adjusted values for CF-PWV but not CAVI were higher in presence of MetS (CF-PWV: 9.57±0.06 vs. 8.65±0.10, P<0.001; CAVI: 8.34±0.03 vs. 8.29±0.04, P=0.40; mean±SEM; MetS vs. no MetS). The absence of an overall effect of MetS on CAVI was related to the heterogeneous effects of the components of MetS on this parameter: CAVI was positively associated with the high glycaemia and high blood pressure components, whereas lacked significant associations with the HDL and triglycerides components while exhibiting a negative association with the overweight component. In contrast, all five MetS components showed positive associations with CF-PWV. Conclusion: This large European multicentre study reveals a differential impact of MetS and age on CAVI and CF PWV and suggests that age may have a more pronounced effect on CAVI, whereas MetS increases CF-PWV but not CAVI. This important finding may be due to heterogeneous effects of MetS components on CAVI. The clinical significance of these original results will be assessed during the longitudinal phase of the study.",

keywords = "Arterial tiffness, Cardio-ankle ascular index, Large artery, Metabolic syndrome, Pulse wave velocity, ging",

author = "Jirar Topouchian and Carlos Labat and Sylvie Gautier and Magnus B{\"a}ck and Apostolos Achimastos and Jacques Blacher and Marcin Cwynar and \{De La Sierra\}, Alejandro and Denes Pall and Francesco Fantin and Katalin Farkas and Luis Garcia-Ortiz and Zoya Hakobyan and Piotr Jankowski and Ana Jelakovic and Zhanna Kobalava and Alexandra Konradi and Yulia Kotovskaya and Marina Kotsani and Irina Lazareva and Alexander Litvin and Viktor Milyagin and Iveta Mintale and Oscar Persson and Rafael Ramos and Anatoly Rogoza and Ligita Ryliskyte and Angelo Scuteri and Yuriy Sirenko and Georges Soulis and Nebojsa Tasic and Maryna Udovychenko and Saule Urazalina and Peter Wohlfahrt and Parounak Zelveian and Athanase Benetos and Roland Asmar",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 The Author(s).",

year = "2018",

month = apr,

doi = "10.1097/HJH.0000000000001631",

language = "English",

volume = "36",

pages = "824--833",

journal = "Journal of Hypertension",

issn = "0263-6352",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

Topouchian, J, Labat, C, Gautier, S, Bäck, M, Achimastos, A, Blacher, J, Cwynar, M, De La Sierra, A, Pall, D, Fantin, F, Farkas, K, Garcia-Ortiz, L, Hakobyan, Z, Jankowski, P, Jelakovic, A, Kobalava, Z, Konradi, A, Kotovskaya, Y, Kotsani, M, Lazareva, I, Litvin, A, Milyagin, V, Mintale, I, Persson, O, Ramos, R, Rogoza, A, Ryliskyte, L, Scuteri, A, Sirenko, Y, Soulis, G, Tasic, N, Udovychenko, M, Urazalina, S, Wohlfahrt, P, Zelveian, P, Benetos, A & Asmar, R 2018, 'Effects of metabolic syndrome on arterial function in different age groups: The Advanced Approach to Arterial Stiffness study', Journal of Hypertension, vol. 36, no. 4, pp. 824-833. https://doi.org/10.1097/HJH.0000000000001631

TY - JOUR

T1 - Effects of metabolic syndrome on arterial function in different age groups

T2 - The Advanced Approach to Arterial Stiffness study

AU - Topouchian, Jirar

AU - Labat, Carlos

AU - Gautier, Sylvie

AU - Bäck, Magnus

AU - Achimastos, Apostolos

AU - Blacher, Jacques

AU - Cwynar, Marcin

AU - De La Sierra, Alejandro

AU - Pall, Denes

AU - Fantin, Francesco

AU - Farkas, Katalin

AU - Garcia-Ortiz, Luis

AU - Hakobyan, Zoya

AU - Jankowski, Piotr

AU - Jelakovic, Ana

AU - Kobalava, Zhanna

AU - Konradi, Alexandra

AU - Kotovskaya, Yulia

AU - Kotsani, Marina

AU - Lazareva, Irina

AU - Litvin, Alexander

AU - Milyagin, Viktor

AU - Mintale, Iveta

AU - Persson, Oscar

AU - Ramos, Rafael

AU - Rogoza, Anatoly

AU - Ryliskyte, Ligita

AU - Scuteri, Angelo

AU - Sirenko, Yuriy

AU - Soulis, Georges

AU - Tasic, Nebojsa

AU - Udovychenko, Maryna

AU - Urazalina, Saule

AU - Wohlfahrt, Peter

AU - Zelveian, Parounak

AU - Benetos, Athanase

AU - Asmar, Roland

PY - 2018/4

Y1 - 2018/4

N2 - Objective: The aim of the Advanced Approach to Arterial Stiffness study was to compare arterial stiffness measured simultaneously with two different methods in different age groups of middle-aged and older adults with or without metabolic syndrome (MetS). The specific effects of the different MetS components on arterial stiffness were also studied. Methods: This prospective, multicentre, international study included 2224 patients aged 40 years and older, 1664 with and 560 without MetS. Patients were enrolled in 32 centres from 18 European countries affiliated to the International Society of Vascular Health & Aging. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) and the carotid-femoral pulse wave velocity (CF-PWV) in four prespecified age groups: 40-49, 50-59, 60-74, 75-90 years. In this report, we present the baseline data of this study. Results: Both CF-PWV and CAVI increased with age, with a higher correlation coefficient for CAVI (comparison of coefficients P<0.001). Age-adjusted and sex-adjusted values of CF-PWV and CAVI were weakly intercorrelated (r2=0.06, P<0.001). Age-adjusted and sex-adjusted values for CF-PWV but not CAVI were higher in presence of MetS (CF-PWV: 9.57±0.06 vs. 8.65±0.10, P<0.001; CAVI: 8.34±0.03 vs. 8.29±0.04, P=0.40; mean±SEM; MetS vs. no MetS). The absence of an overall effect of MetS on CAVI was related to the heterogeneous effects of the components of MetS on this parameter: CAVI was positively associated with the high glycaemia and high blood pressure components, whereas lacked significant associations with the HDL and triglycerides components while exhibiting a negative association with the overweight component. In contrast, all five MetS components showed positive associations with CF-PWV. Conclusion: This large European multicentre study reveals a differential impact of MetS and age on CAVI and CF PWV and suggests that age may have a more pronounced effect on CAVI, whereas MetS increases CF-PWV but not CAVI. This important finding may be due to heterogeneous effects of MetS components on CAVI. The clinical significance of these original results will be assessed during the longitudinal phase of the study.

AB - Objective: The aim of the Advanced Approach to Arterial Stiffness study was to compare arterial stiffness measured simultaneously with two different methods in different age groups of middle-aged and older adults with or without metabolic syndrome (MetS). The specific effects of the different MetS components on arterial stiffness were also studied. Methods: This prospective, multicentre, international study included 2224 patients aged 40 years and older, 1664 with and 560 without MetS. Patients were enrolled in 32 centres from 18 European countries affiliated to the International Society of Vascular Health & Aging. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) and the carotid-femoral pulse wave velocity (CF-PWV) in four prespecified age groups: 40-49, 50-59, 60-74, 75-90 years. In this report, we present the baseline data of this study. Results: Both CF-PWV and CAVI increased with age, with a higher correlation coefficient for CAVI (comparison of coefficients P<0.001). Age-adjusted and sex-adjusted values of CF-PWV and CAVI were weakly intercorrelated (r2=0.06, P<0.001). Age-adjusted and sex-adjusted values for CF-PWV but not CAVI were higher in presence of MetS (CF-PWV: 9.57±0.06 vs. 8.65±0.10, P<0.001; CAVI: 8.34±0.03 vs. 8.29±0.04, P=0.40; mean±SEM; MetS vs. no MetS). The absence of an overall effect of MetS on CAVI was related to the heterogeneous effects of the components of MetS on this parameter: CAVI was positively associated with the high glycaemia and high blood pressure components, whereas lacked significant associations with the HDL and triglycerides components while exhibiting a negative association with the overweight component. In contrast, all five MetS components showed positive associations with CF-PWV. Conclusion: This large European multicentre study reveals a differential impact of MetS and age on CAVI and CF PWV and suggests that age may have a more pronounced effect on CAVI, whereas MetS increases CF-PWV but not CAVI. This important finding may be due to heterogeneous effects of MetS components on CAVI. The clinical significance of these original results will be assessed during the longitudinal phase of the study.

KW - Arterial tiffness

KW - Cardio-ankle ascular index

KW - Large artery

KW - Metabolic syndrome

KW - Pulse wave velocity

KW - ging

UR - https://www.scopus.com/pages/publications/85046301598

U2 - 10.1097/HJH.0000000000001631

DO - 10.1097/HJH.0000000000001631

M3 - Article

C2 - 29324585

AN - SCOPUS:85046301598

SN - 0263-6352

VL - 36

SP - 824

EP - 833

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 4

ER -

Effects of metabolic syndrome on arterial function in different age groups: The Advanced Approach to Arterial Stiffness study

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this