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EPR and FTIR spectroscopies study of human blood after irradiation

  • M. Polakovs*
  • , N. Mironova-Ulmane
  • , A. Pavlenko
  • , E. Reinholds
  • , M. Gavare
  • , M. Grube
  • *Corresponding author for this work
  • University of Latvia
  • Paula Stradina Clinical University Hospital

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

2 Citations (Scopus)

Abstract

In the present work we report results of investigations of human blood before and after radioisotope Tc99m diagnosis by Electron paramagnetic resonance (EPR) and Fourier transform infrared (FTIR) spectroscopies. It is shown, that EPR can detect the concentration of methaemoglobin and transferrin ions of more accurately than any other technique. FTIR spectra indicated radiation caused conformational and concentration changes of proteins. Hierarchical cluster analysis (HCA) was created as time-saving tool for discrimination of initial and irradiated in vivo human blood samples.

Original languageEnglish
Title of host publicationSpectroscopy of Biological Molecules. Proceedings from the 14th European Conference on the Spectroscopy of Biological Molecules 2011
EditorsMaria Marques, Luis Batista de Carvalho, Parvez Haris
Pages215-219
Number of pages5
DOIs
Publication statusPublished - 2013

Publication series

NameAdvances in Biomedical Spectroscopy
Volume7
ISSN (Print)1875-0656

Keywords

  • blood
  • EPR (Electron paramagnetic resonance)
  • FTIR (Fourier transform infrared)
  • hemoglobin
  • radioisotope Tc99m diagnosis
  • spectroscopy

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