Frequency and type of microbiological monitoring of multidrug-resistant tuberculosis treatment

Ekaterina V. Kurbatova; V. M. Gammino; J. Bayona; M. Becerra; M. Danilovitz; D. Falzon; I. Gelmanova; S. Keshavjee; V. Leimane; C. D. Mitnick; M. I.D. Quelapio; V. Riekstina; A. Taylor; P. Viiklepp; M. Zignol; J. P. Cegielski

doi:10.5588/ijtld.11.0101

Frequency and type of microbiological monitoring of multidrug-resistant tuberculosis treatment

Ekaterina V. Kurbatova^*
, V. M. Gammino
, J. Bayona
, M. Becerra
, M. Danilovitz
, D. Falzon
, I. Gelmanova
, S. Keshavjee
, V. Leimane
, C. D. Mitnick
, M. I.D. Quelapio
, V. Riekstina
, A. Taylor
, P. Viiklepp
, M. Zignol
, J. P. Cegielski

^*Corresponding author for this work

Centers for Disease Control and Prevention
Partners in Health
Harvard University
Eye Clinic of Tartu University Hospital
World Health Organization
Infectology Center of Latvia
Tropical Disease Foundation
National Institute for Health Development

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Monthly culture is usually recommended to monitor treatment of multidrug-resistant tuberculosis (MDR-TB). As mycobacterial laboratory capacity is limited in many settings, TB programs need evidence to decide whether monthly cultures are necessary compared to other approaches. We simulated three alternative monitoring strategies (culture every 2 or 3 months, and monthly smears alone) in a cohort of MDR-TB patients in Estonia, Latvia, Philippines, Russia and Peru from 2000 to 2004. This retrospective analysis illustrated that less frequent testing delays confirmation of bacteriological conversion. This would prolong intensive treatment, hospitalization and respiratory isolation, increasing cost and toxicity. After conversion, less frequent testing could delay diagnosis of possible treatment failure.

Original language	English
Pages (from-to)	1553-1555
Number of pages	3
Journal	International Journal of Tuberculosis and Lung Disease
Volume	15
Issue number	11
DOIs	https://doi.org/10.5588/ijtld.11.0101
Publication status	Published - Nov 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Culture conversion
MDR-TB
Monitoring
Treatment response

Access to Document

10.5588/ijtld.11.0101

Cite this

Kurbatova, E. V., Gammino, V. M., Bayona, J., Becerra, M., Danilovitz, M., Falzon, D., Gelmanova, I., Keshavjee, S., Leimane, V., Mitnick, C. D., Quelapio, M. I. D., Riekstina, V., Taylor, A., Viiklepp, P., Zignol, M., & Cegielski, J. P. (2011). Frequency and type of microbiological monitoring of multidrug-resistant tuberculosis treatment. International Journal of Tuberculosis and Lung Disease, 15(11), 1553-1555. https://doi.org/10.5588/ijtld.11.0101

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title = "Frequency and type of microbiological monitoring of multidrug-resistant tuberculosis treatment",

abstract = "Monthly culture is usually recommended to monitor treatment of multidrug-resistant tuberculosis (MDR-TB). As mycobacterial laboratory capacity is limited in many settings, TB programs need evidence to decide whether monthly cultures are necessary compared to other approaches. We simulated three alternative monitoring strategies (culture every 2 or 3 months, and monthly smears alone) in a cohort of MDR-TB patients in Estonia, Latvia, Philippines, Russia and Peru from 2000 to 2004. This retrospective analysis illustrated that less frequent testing delays confirmation of bacteriological conversion. This would prolong intensive treatment, hospitalization and respiratory isolation, increasing cost and toxicity. After conversion, less frequent testing could delay diagnosis of possible treatment failure.",

keywords = "Culture conversion, MDR-TB, Monitoring, Treatment response",

author = "Kurbatova, \{Ekaterina V.\} and Gammino, \{V. M.\} and J. Bayona and M. Becerra and M. Danilovitz and D. Falzon and I. Gelmanova and S. Keshavjee and V. Leimane and Mitnick, \{C. D.\} and Quelapio, \{M. I.D.\} and V. Riekstina and A. Taylor and P. Viiklepp and M. Zignol and Cegielski, \{J. P.\}",

year = "2011",

month = nov,

doi = "10.5588/ijtld.11.0101",

language = "English",

volume = "15",

pages = "1553--1555",

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Kurbatova, EV, Gammino, VM, Bayona, J, Becerra, M, Danilovitz, M, Falzon, D, Gelmanova, I, Keshavjee, S, Leimane, V, Mitnick, CD, Quelapio, MID, Riekstina, V, Taylor, A, Viiklepp, P, Zignol, M & Cegielski, JP 2011, 'Frequency and type of microbiological monitoring of multidrug-resistant tuberculosis treatment', International Journal of Tuberculosis and Lung Disease, vol. 15, no. 11, pp. 1553-1555. https://doi.org/10.5588/ijtld.11.0101

TY - JOUR

T1 - Frequency and type of microbiological monitoring of multidrug-resistant tuberculosis treatment

AU - Kurbatova, Ekaterina V.

AU - Gammino, V. M.

AU - Bayona, J.

AU - Becerra, M.

AU - Danilovitz, M.

AU - Falzon, D.

AU - Gelmanova, I.

AU - Keshavjee, S.

AU - Leimane, V.

AU - Mitnick, C. D.

AU - Quelapio, M. I.D.

AU - Riekstina, V.

AU - Taylor, A.

AU - Viiklepp, P.

AU - Zignol, M.

AU - Cegielski, J. P.

PY - 2011/11

Y1 - 2011/11

N2 - Monthly culture is usually recommended to monitor treatment of multidrug-resistant tuberculosis (MDR-TB). As mycobacterial laboratory capacity is limited in many settings, TB programs need evidence to decide whether monthly cultures are necessary compared to other approaches. We simulated three alternative monitoring strategies (culture every 2 or 3 months, and monthly smears alone) in a cohort of MDR-TB patients in Estonia, Latvia, Philippines, Russia and Peru from 2000 to 2004. This retrospective analysis illustrated that less frequent testing delays confirmation of bacteriological conversion. This would prolong intensive treatment, hospitalization and respiratory isolation, increasing cost and toxicity. After conversion, less frequent testing could delay diagnosis of possible treatment failure.

AB - Monthly culture is usually recommended to monitor treatment of multidrug-resistant tuberculosis (MDR-TB). As mycobacterial laboratory capacity is limited in many settings, TB programs need evidence to decide whether monthly cultures are necessary compared to other approaches. We simulated three alternative monitoring strategies (culture every 2 or 3 months, and monthly smears alone) in a cohort of MDR-TB patients in Estonia, Latvia, Philippines, Russia and Peru from 2000 to 2004. This retrospective analysis illustrated that less frequent testing delays confirmation of bacteriological conversion. This would prolong intensive treatment, hospitalization and respiratory isolation, increasing cost and toxicity. After conversion, less frequent testing could delay diagnosis of possible treatment failure.

KW - Culture conversion

KW - MDR-TB

KW - Monitoring

KW - Treatment response

UR - https://www.scopus.com/pages/publications/80053934718

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DO - 10.5588/ijtld.11.0101

M3 - Article

C2 - 22008772

AN - SCOPUS:80053934718

SN - 1027-3719

VL - 15

SP - 1553

EP - 1555

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 11

ER -

Frequency and type of microbiological monitoring of multidrug-resistant tuberculosis treatment

Abstract

UN SDGs

Keywords

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