High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Philippe Goyette; Gabrielle Boucher; Dermot Mallon; Eva Ellinghaus; Luke Jostins; Hailiang Huang; Stephan Ripke; Elena S. Gusareva; Vito Annese; Stephen L. Hauser; Jorge R. Oksenberg; Ingo Thomsen; Stephen Leslie; Mark J. Daly; Kristel Van Steen; Richard H. Duerr; Jeffrey C. Barrett; Dermot P B McGovern; L. Philip Schumm; James A. Traherne; Mary N. Carrington; Vasilis Kosmoliaptsis; Tom H. Karlsen; Andre Franke; John D. Rioux; Clara Abraham; Jean Paul Achkar; Tariq Ahmad; Leila Amininejad; Ashwin N. Ananthakrishnan; Vibeke Andersen; Carl A. Anderson; Jane M. Andrews; Guy Aumais; Leonard Baidoo; Robert N. Baldassano; Tobias Balschun; Peter A. Bampton; Murray Barclay; Theodore M. Bayless; Johannes Bethge; Joshua C. Bis; Alain Bitton; Stephan Brand; Steven R. Brant; Carsten Buning; Angela Chew; Judy H. Cho; Isabelle Cleynen; Ariella Cohain; Anthony Croft; Mauro D'Amato; Silvio Danese; Dirk De Jong; Martine De Vos; Goda Denapiene; Lee A. Denson; Kathy L. Devaney; Olivier Dewit; Renata D'Inca; Marla Dubinsky; Cathryn Edwards; David Ellinghaus; Jonah Essers; Lynnette R. Ferguson; Eleonora A. Festen; Philip Fleshner; Tim Florin; Denis Franchimont; Karin Fransen; Richard Gearry; Michel Georges; Christian Gieger; Jurgen Glas

doi:10.1038/ng.3176

High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Philippe Goyette
, Gabrielle Boucher
, Dermot Mallon
, Eva Ellinghaus
, Luke Jostins
, Hailiang Huang
, Stephan Ripke
, Elena S. Gusareva
, Vito Annese
, Stephen L. Hauser
, Jorge R. Oksenberg
, Ingo Thomsen
, Stephen Leslie
, Mark J. Daly
, Kristel Van Steen
, Richard H. Duerr
, Jeffrey C. Barrett
, Dermot P B McGovern
, L. Philip Schumm
, James A. Traherne

Mary N. Carrington, Vasilis Kosmoliaptsis, Tom H. Karlsen, Andre Franke, John D. Rioux, Clara Abraham, Jean Paul Achkar, Tariq Ahmad, Leila Amininejad, Ashwin N. Ananthakrishnan, Vibeke Andersen, Carl A. Anderson, Jane M. Andrews, Guy Aumais, Leonard Baidoo, Robert N. Baldassano, Tobias Balschun, Peter A. Bampton, Murray Barclay, Theodore M. Bayless, Johannes Bethge, Joshua C. Bis, Alain Bitton, Stephan Brand, Steven R. Brant, Carsten Buning, Angela Chew, Judy H. Cho, Isabelle Cleynen, Ariella Cohain, Anthony Croft, Mauro D'Amato, Silvio Danese, Dirk De Jong, Martine De Vos, Goda Denapiene, Lee A. Denson, Kathy L. Devaney, Olivier Dewit, Renata D'Inca, Marla Dubinsky, Cathryn Edwards, David Ellinghaus, Jonah Essers, Lynnette R. Ferguson, Eleonora A. Festen, Philip Fleshner, Tim Florin, Denis Franchimont, Karin Fransen, Richard Gearry, Michel Georges, Christian Gieger, Jurgen Glas

University of Montreal
University of Cambridge
NIHR Cambridge Biomedical Research Centre
Kiel University
University of Oxford
Massachusetts General Hospital
Broad Institute
University of Liege
IRCCS Ospedale Casa Sollievo della Sofferenza - San Giovanni Rotondo (FG)
Azienda Ospedaliera Careggi
University of California at San Francisco
Murdoch Children's Research Institute
University of Melbourne
University of Pittsburgh
Wellcome Sanger Institute
Cedars-Sinai Medical Center
The University of Chicago
Leidos Biomedical Research, Inc.
Massachusetts Institute of Technology
University of Oslo
Norwegian Primary Sclerosing Cholangitis Research Center
Yale University
Cleveland Clinic Foundation
Peninsula College of Medicine and Dentistry
Université libre de Bruxelles
Free Universities of Brussels
Harvard University
Aarhus University
Hospital of Southern Jutland
Royal Adelaide Hospital
Hopital Maisonneuve-Rosemont
Children’s Hospital of Philadelphia
Flinders University
University of Otago
Johns Hopkins University
University of Washington
Royal Victoria Hospital Barrie
Ludwig Maximilian University of Munich
Charité – Universitätsmedizin Berlin
Fremantle Hospital
University of Western Australia
KU Leuven
Icahn School of Medicine at Mount Sinai
Queensland Institute of Medical Research
Karolinska Institutet
IRCCS Istituto Clinico Humanitas - Rozzano (Milano)
Radboud University Nijmegen
Ghent University
Vilnius University
Cincinnati Children's Hospital Medical Center
Université catholique de Louvain
Azienda Ospedaliera di Padova
Torbay and South Devon NHS Foundation Trust
Medical and Health Sciences, University of Auckland
University of Groningen
Mater Group
Canterbury District Health Board
Helmholtz Zentrum München - German Research Center for Environmental Health

Research output: Contribution to journal › Article › peer-review

282 Citations (Scopus)

Original language	English
Pages (from-to)	172-179
Journal	Nature Genetics
Volume	47
Issue number	2
DOIs	https://doi.org/10.1038/ng.3176
Publication status	Published - 2015

OECD Field of Science

3. Medical and Health Sciences

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10.1038/ng.3176

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Goyette, P., Boucher, G., Mallon, D., Ellinghaus, E., Jostins, L., Huang, H., Ripke, S., Gusareva, E. S., Annese, V., Hauser, S. L., Oksenberg, J. R., Thomsen, I., Leslie, S., Daly, M. J., Van Steen, K., Duerr, R. H., Barrett, J. C., McGovern, D. P. B., Schumm, L. P., ... Glas, J. (2015). High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nature Genetics, 47(2), 172-179. https://doi.org/10.1038/ng.3176

@article{4ba9f2ff06034f788f20502de17e7198,

title = "High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis",

author = "Philippe Goyette and Gabrielle Boucher and Dermot Mallon and Eva Ellinghaus and Luke Jostins and Hailiang Huang and Stephan Ripke and Gusareva, \{Elena S.\} and Vito Annese and Hauser, \{Stephen L.\} and Oksenberg, \{Jorge R.\} and Ingo Thomsen and Stephen Leslie and Daly, \{Mark J.\} and \{Van Steen\}, Kristel and Duerr, \{Richard H.\} and Barrett, \{Jeffrey C.\} and McGovern, \{Dermot P B\} and Schumm, \{L. Philip\} and Traherne, \{James A.\} and Carrington, \{Mary N.\} and Vasilis Kosmoliaptsis and Karlsen, \{Tom H.\} and Andre Franke and Rioux, \{John D.\} and Clara Abraham and Achkar, \{Jean Paul\} and Tariq Ahmad and Leila Amininejad and Ananthakrishnan, \{Ashwin N.\} and Vibeke Andersen and Anderson, \{Carl A.\} and Andrews, \{Jane M.\} and Guy Aumais and Leonard Baidoo and Baldassano, \{Robert N.\} and Tobias Balschun and Bampton, \{Peter A.\} and Murray Barclay and Bayless, \{Theodore M.\} and Johannes Bethge and Bis, \{Joshua C.\} and Alain Bitton and Stephan Brand and Brant, \{Steven R.\} and Carsten Buning and Angela Chew and Cho, \{Judy H.\} and Isabelle Cleynen and Ariella Cohain and Anthony Croft and Mauro D'Amato and Silvio Danese and \{De Jong\}, Dirk and \{De Vos\}, Martine and Goda Denapiene and Denson, \{Lee A.\} and Devaney, \{Kathy L.\} and Olivier Dewit and Renata D'Inca and Marla Dubinsky and Cathryn Edwards and David Ellinghaus and Jonah Essers and Ferguson, \{Lynnette R.\} and Festen, \{Eleonora A.\} and Philip Fleshner and Tim Florin and Denis Franchimont and Karin Fransen and Richard Gearry and Michel Georges and Christian Gieger and Jurgen Glas",

year = "2015",

doi = "10.1038/ng.3176",

language = "English",

volume = "47",

pages = "172--179",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "2",

}

Goyette, P, Boucher, G, Mallon, D, Ellinghaus, E, Jostins, L, Huang, H, Ripke, S, Gusareva, ES, Annese, V, Hauser, SL, Oksenberg, JR, Thomsen, I, Leslie, S, Daly, MJ, Van Steen, K, Duerr, RH, Barrett, JC, McGovern, DPB, Schumm, LP, Traherne, JA, Carrington, MN, Kosmoliaptsis, V, Karlsen, TH, Franke, A, Rioux, JD, Abraham, C, Achkar, JP, Ahmad, T, Amininejad, L, Ananthakrishnan, AN, Andersen, V, Anderson, CA, Andrews, JM, Aumais, G, Baidoo, L, Baldassano, RN, Balschun, T, Bampton, PA, Barclay, M, Bayless, TM, Bethge, J, Bis, JC, Bitton, A, Brand, S, Brant, SR, Buning, C, Chew, A, Cho, JH, Cleynen, I, Cohain, A, Croft, A, D'Amato, M, Danese, S, De Jong, D, De Vos, M, Denapiene, G, Denson, LA, Devaney, KL, Dewit, O, D'Inca, R, Dubinsky, M, Edwards, C, Ellinghaus, D, Essers, J, Ferguson, LR, Festen, EA, Fleshner, P, Florin, T, Franchimont, D, Fransen, K, Gearry, R, Georges, M, Gieger, C & Glas, J 2015, 'High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis', Nature Genetics, vol. 47, no. 2, pp. 172-179. https://doi.org/10.1038/ng.3176

TY - JOUR

T1 - High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

AU - Goyette, Philippe

AU - Boucher, Gabrielle

AU - Mallon, Dermot

AU - Ellinghaus, Eva

AU - Jostins, Luke

AU - Huang, Hailiang

AU - Ripke, Stephan

AU - Gusareva, Elena S.

AU - Annese, Vito

AU - Hauser, Stephen L.

AU - Oksenberg, Jorge R.

AU - Thomsen, Ingo

AU - Leslie, Stephen

AU - Daly, Mark J.

AU - Van Steen, Kristel

AU - Duerr, Richard H.

AU - Barrett, Jeffrey C.

AU - McGovern, Dermot P B

AU - Schumm, L. Philip

AU - Traherne, James A.

AU - Carrington, Mary N.

AU - Kosmoliaptsis, Vasilis

AU - Karlsen, Tom H.

AU - Franke, Andre

AU - Rioux, John D.

AU - Abraham, Clara

AU - Achkar, Jean Paul

AU - Ahmad, Tariq

AU - Amininejad, Leila

AU - Ananthakrishnan, Ashwin N.

AU - Andersen, Vibeke

AU - Anderson, Carl A.

AU - Andrews, Jane M.

AU - Aumais, Guy

AU - Baidoo, Leonard

AU - Baldassano, Robert N.

AU - Balschun, Tobias

AU - Bampton, Peter A.

AU - Barclay, Murray

AU - Bayless, Theodore M.

AU - Bethge, Johannes

AU - Bis, Joshua C.

AU - Bitton, Alain

AU - Brand, Stephan

AU - Brant, Steven R.

AU - Buning, Carsten

AU - Chew, Angela

AU - Cho, Judy H.

AU - Cleynen, Isabelle

AU - Cohain, Ariella

AU - Croft, Anthony

AU - D'Amato, Mauro

AU - Danese, Silvio

AU - De Jong, Dirk

AU - De Vos, Martine

AU - Denapiene, Goda

AU - Denson, Lee A.

AU - Devaney, Kathy L.

AU - Dewit, Olivier

AU - D'Inca, Renata

AU - Dubinsky, Marla

AU - Edwards, Cathryn

AU - Ellinghaus, David

AU - Essers, Jonah

AU - Ferguson, Lynnette R.

AU - Festen, Eleonora A.

AU - Fleshner, Philip

AU - Florin, Tim

AU - Franchimont, Denis

AU - Fransen, Karin

AU - Gearry, Richard

AU - Georges, Michel

AU - Gieger, Christian

AU - Glas, Jurgen

PY - 2015

Y1 - 2015

UR - http://www.nature.com/ng/journal/v47/n2/full/ng.3176.html

U2 - 10.1038/ng.3176

DO - 10.1038/ng.3176

M3 - Article

C2 - 25559196

SN - 1061-4036

VL - 47

SP - 172

EP - 179

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

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