Indutsirovannaia T-limfotsitami normalizatsiia transformirovannykh zlokachestvennykh fibroblastov: limfokin s aktivnost'iu faktora normalizatsii.

I. I. Stonans; N. K. Gorlina; A. N. Cheredeev; M. E. Bogdanov; O. A. Khoperskaia; N. V. Kushnir; I. G. Kozlov

Indutsirovannaia T-limfotsitami normalizatsiia transformirovannykh zlokachestvennykh fibroblastov: limfokin s aktivnost'iu faktora normalizatsii.

Translated title of the contribution: T-lymphocyte induced normalization of transformed malignant fibroblasts: lymphokine with normalization factor activity

I. I. Stonans^*
, N. K. Gorlina
, A. N. Cheredeev
, M. E. Bogdanov
, O. A. Khoperskaia
, N. V. Kushnir
, I. G. Kozlov

^*Corresponding author for this work

Institute of Clinical and Preventive Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Normalizing influence of different lymphocyte populations and their soluble factors on L-929 transformed malignant fibroblasts (L cells) has been examined. It was demonstrated that splenic T-lymphocytes caused stable (heritable) normalization of receptor apparatus, biophysical and proliferative characteristics of L cells. Lymphokine with the activity of normalization factor (NF) was purified from 24-hour immunocyte conditioned medium. Stability of the normalization phenomenon was caused by NF induced synthesis of functionally analogous factor in L cells. The results obtained indicate the existence of non-cytotoxic mechanisms of tumour growth immunological control. The isolated lymphokine possessed also the activity of early embryonal cell differentiation factor. It is suggested that lymphokines with the activity of NF are physiological regulators of nonlymphoid cell differentiation.

Translated title of the contribution	T-lymphocyte induced normalization of transformed malignant fibroblasts: lymphokine with normalization factor activity
Original language	Russian
Pages (from-to)	473-475
Number of pages	3
Journal	Byulleten Eksperimentalnoi Biologii i Meditsiny
Volume	108
Issue number	10
Publication status	Published - Oct 1989

Cite this

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title = "Indutsirovannaia T-limfotsitami normalizatsiia transformirovannykh zlokachestvennykh fibroblastov: limfokin s aktivnost'iu faktora normalizatsii.",

abstract = "Normalizing influence of different lymphocyte populations and their soluble factors on L-929 transformed malignant fibroblasts (L cells) has been examined. It was demonstrated that splenic T-lymphocytes caused stable (heritable) normalization of receptor apparatus, biophysical and proliferative characteristics of L cells. Lymphokine with the activity of normalization factor (NF) was purified from 24-hour immunocyte conditioned medium. Stability of the normalization phenomenon was caused by NF induced synthesis of functionally analogous factor in L cells. The results obtained indicate the existence of non-cytotoxic mechanisms of tumour growth immunological control. The isolated lymphokine possessed also the activity of early embryonal cell differentiation factor. It is suggested that lymphokines with the activity of NF are physiological regulators of nonlymphoid cell differentiation.",

author = "Stonans, \{I. I.\} and Gorlina, \{N. K.\} and Cheredeev, \{A. N.\} and Bogdanov, \{M. E.\} and Khoperskaia, \{O. A.\} and Kushnir, \{N. V.\} and Kozlov, \{I. G.\}",

year = "1989",

month = oct,

language = "Krievu",

volume = "108",

pages = "473--475",

journal = "Byulleten Eksperimentalnoi Biologii i Meditsiny",

issn = "0365-9615",

publisher = "Rossiiskaya Akademiya Meditsinskikh Nauk",

number = "10",

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TY - JOUR

T1 - Indutsirovannaia T-limfotsitami normalizatsiia transformirovannykh zlokachestvennykh fibroblastov

T2 - limfokin s aktivnost'iu faktora normalizatsii.

AU - Stonans, I. I.

AU - Gorlina, N. K.

AU - Cheredeev, A. N.

AU - Bogdanov, M. E.

AU - Khoperskaia, O. A.

AU - Kushnir, N. V.

AU - Kozlov, I. G.

PY - 1989/10

Y1 - 1989/10

N2 - Normalizing influence of different lymphocyte populations and their soluble factors on L-929 transformed malignant fibroblasts (L cells) has been examined. It was demonstrated that splenic T-lymphocytes caused stable (heritable) normalization of receptor apparatus, biophysical and proliferative characteristics of L cells. Lymphokine with the activity of normalization factor (NF) was purified from 24-hour immunocyte conditioned medium. Stability of the normalization phenomenon was caused by NF induced synthesis of functionally analogous factor in L cells. The results obtained indicate the existence of non-cytotoxic mechanisms of tumour growth immunological control. The isolated lymphokine possessed also the activity of early embryonal cell differentiation factor. It is suggested that lymphokines with the activity of NF are physiological regulators of nonlymphoid cell differentiation.

AB - Normalizing influence of different lymphocyte populations and their soluble factors on L-929 transformed malignant fibroblasts (L cells) has been examined. It was demonstrated that splenic T-lymphocytes caused stable (heritable) normalization of receptor apparatus, biophysical and proliferative characteristics of L cells. Lymphokine with the activity of normalization factor (NF) was purified from 24-hour immunocyte conditioned medium. Stability of the normalization phenomenon was caused by NF induced synthesis of functionally analogous factor in L cells. The results obtained indicate the existence of non-cytotoxic mechanisms of tumour growth immunological control. The isolated lymphokine possessed also the activity of early embryonal cell differentiation factor. It is suggested that lymphokines with the activity of NF are physiological regulators of nonlymphoid cell differentiation.

UR - https://www.scopus.com/pages/publications/0024741044

M3 - Zinātniskais raksts (žurnālā)

C2 - 2597764

AN - SCOPUS:0024741044

SN - 0365-9615

VL - 108

SP - 473

EP - 475

JO - Byulleten Eksperimentalnoi Biologii i Meditsiny

JF - Byulleten Eksperimentalnoi Biologii i Meditsiny

IS - 10

ER -

Indutsirovannaia T-limfotsitami normalizatsiia transformirovannykh zlokachestvennykh fibroblastov: limfokin s aktivnost'iu faktora normalizatsii.

Abstract

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