Izmeneniia makromolekuliarnogo sostava i organizatsii kletochnogo iadra pri gameto-, émbrio- i histogeneze.

Data about changes in the molecular organization of the cell nucleus during the organism development and tissue differentiation are summarized. The peculiarities of the nucleus organization of gametes, its changes in the course of fertilization and early embryogenesis are discussed. Data concerning different objects of developmental biology are reviewed separately. The data about tissue specificity of the chromatin structure and characteristic features of nuclei of nervous, muscle, epithelial, and connective tissue cells are also presented. Different levels of chromatin organization, i.e., the primary and secondary DNA structure, protein composition, nucleosomal and supranucleosomal structures, DNA supercoiling in chromatin domains, nuclear skeleton structures, are specifically concerned in each particular case.