Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System

Aivars Cīrulis; Ivars Silamiķelis; Edgars Laķis; Kaspars Megnis; Angelika Voronova; Laura Ansone; Janis Pjalkovskis; Rolands Strazdiņš; Monta Brīvība; Jānis Kloviņš

doi:10.2478/prolas-2026-0007

Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System

Aivars Cīrulis^*
, Ivars Silamiķelis
, Edgars Laķis
, Kaspars Megnis
, Angelika Voronova
, Laura Ansone
, Janis Pjalkovskis
, Rolands Strazdiņš
, Monta Brīvība
, Jānis Kloviņš

^*Corresponding author for this work

Latvian Biomedical Research and Study Centre
Latvian Institute of Organic Synthesis

Research output: Contribution to journal › Meeting abstract › peer-review

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Abstract

Baltic populations are often underrepresented in genomic resources, hindering the interpretation of variants, the calculation of polygenic risk scores (PRSs), and disease estimates. The development of a population-scale reference dataset of Latvian genetic variation may bridge the gap in European genomes by improving imputation and variant interpretation. These benefits are maximised when the dataset is integrated into broader frameworks, such as the Genome of Europe (GoE).

Original language	English
Pages (from-to)	49-49
Journal	Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume	80
Issue number	1/2
DOIs	https://doi.org/10.2478/prolas-2026-0007
Publication status	Published - May 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

OECD Field of Science

3.5 Other Medical Sciences
1.6 Biological Sciences

Keywords

Genome reference
Genomic database
Latvia

Access to Document

10.2478/prolas-2026-0007Licence: CC BY-NC-ND

Public_Health_and_Epidemiology_International_Scientific_Conference_on_Medicine_and_Health_Sciences_oFinal published version, 117 KB

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Cīrulis, A., Silamiķelis, I., Laķis, E., Megnis, K., Voronova, A., Ansone, L., Pjalkovskis, J., Strazdiņš, R., Brīvība, M., & Kloviņš, J. (2026). Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 80(1/2), 49-49. https://doi.org/10.2478/prolas-2026-0007

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title = "Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System",

abstract = "Baltic populations are often underrepresented in genomic resources, hindering the interpretation of variants, the calculation of polygenic risk scores (PRSs), and disease estimates. The development of a population-scale reference dataset of Latvian genetic variation may bridge the gap in European genomes by improving imputation and variant interpretation. These benefits are maximised when the dataset is integrated into broader frameworks, such as the Genome of Europe (GoE).",

keywords = "Genome reference, Genomic database, Latvia",

author = "Aivars Cīrulis and Ivars Silamiķelis and Edgars Laķis and Kaspars Megnis and Angelika Voronova and Laura Ansone and Janis Pjalkovskis and Rolands Strazdiņ{\v s} and Monta Brīvība and Jānis Kloviņ{\v s}",

year = "2026",

month = may,

doi = "10.2478/prolas-2026-0007",

language = "English",

volume = "80",

pages = "49--49",

journal = "Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences",

issn = "1407-009X",

publisher = "Latvian Academy of Sciences",

number = "1/2",

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Cīrulis, A, Silamiķelis, I, Laķis, E, Megnis, K, Voronova, A, Ansone, L, Pjalkovskis, J, Strazdiņš, R, Brīvība, M & Kloviņš, J 2026, 'Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 80, no. 1/2, pp. 49-49. https://doi.org/10.2478/prolas-2026-0007

Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System. / Cīrulis, Aivars; Silamiķelis, Ivars; Laķis, Edgars et al.
In: Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, Vol. 80, No. 1/2, 05.2026, p. 49-49.

Research output: Contribution to journal › Meeting abstract › peer-review

TY - JOUR

T1 - Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System

AU - Cīrulis, Aivars

AU - Silamiķelis, Ivars

AU - Laķis, Edgars

AU - Megnis, Kaspars

AU - Voronova, Angelika

AU - Ansone, Laura

AU - Pjalkovskis, Janis

AU - Strazdiņš, Rolands

AU - Brīvība, Monta

AU - Kloviņš, Jānis

PY - 2026/5

Y1 - 2026/5

N2 - Baltic populations are often underrepresented in genomic resources, hindering the interpretation of variants, the calculation of polygenic risk scores (PRSs), and disease estimates. The development of a population-scale reference dataset of Latvian genetic variation may bridge the gap in European genomes by improving imputation and variant interpretation. These benefits are maximised when the dataset is integrated into broader frameworks, such as the Genome of Europe (GoE).

AB - Baltic populations are often underrepresented in genomic resources, hindering the interpretation of variants, the calculation of polygenic risk scores (PRSs), and disease estimates. The development of a population-scale reference dataset of Latvian genetic variation may bridge the gap in European genomes by improving imputation and variant interpretation. These benefits are maximised when the dataset is integrated into broader frameworks, such as the Genome of Europe (GoE).

KW - Genome reference

KW - Genomic database

KW - Latvia

U2 - 10.2478/prolas-2026-0007

DO - 10.2478/prolas-2026-0007

M3 - Meeting abstract

SN - 1407-009X

VL - 80

SP - 49

EP - 49

JO - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

JF - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

IS - 1/2

ER -

Cīrulis A, Silamiķelis I, Laķis E, Megnis K, Voronova A, Ansone L et al. Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences. 2026 May;80(1/2):49-49. doi: 10.2478/prolas-2026-0007

Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System

Abstract

UN SDGs

OECD Field of Science

Keywords

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