Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite

Andris Antuzevičs; Arita Dubņika; A Antuzevics; A. Dubnika; A Dubnika; T Goto; A Kizalaite; T. Murauskas; A. Kizalaite; A Zarkov; T Murauskas; O Jr Stewart; T Goto; T Murauskas; T. Goto; O. Stewart; S.L. Stoll; A Antuzevics; T. Sekino; A Antuzevics; A. Zarkov; A Kizalaite; A Kizalaite; T Goto; A Kizalaite; A Zarkov; T Murauskas; A Dubnika; A Antuzevics; A Zarkov; T Murauskas; T Goto; A Zarkov; A Dubnika

doi:10.1016/j.ceramint.2024.05.157

Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite

Andris Antuzevičs
, Arita Dubņika
, A Antuzevics
, A. Dubnika
, A Dubnika
, T Goto
, A Kizalaite
, T. Murauskas
, A. Kizalaite
, A Zarkov
, T Murauskas
, O Jr Stewart
, T Goto
, T Murauskas
, T. Goto
, O. Stewart
, S.L. Stoll
, A Antuzevics
, T. Sekino
, A Antuzevics

A. Zarkov, A Kizalaite, A Kizalaite, T Goto, A Kizalaite, A Zarkov, T Murauskas, A Dubnika, A Antuzevics, A Zarkov, T Murauskas, T Goto, A Zarkov, A Dubnika

Institute of Solid State Physics, University of Latvia

Rīgas Tehniskā universitāte
Vilniaus Universitetas
Osaka University
Georgetown University

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

In this work, manganese whitlockite (Mn-WH, Ca₁₈Mn₂(HPO₄)₂(PO₄)₁₂) was successfully synthesized and comprehensively characterized. This material is a manganese-containing analog of the biomineral magnesium whitlockite (Mg-WH, Ca₁₈Mg₂(HPO₄)₂(PO₄)₁₂). The synthesis was performed via a low-temperature dissolution-precipitation process in aqueous medium under ambient pressure at 75 °C using dicalcium phosphate dehydrate and manganese acetate tetrahydrate as starting materials. The crystal structure of the synthesized powder was determined by powder X-ray diffraction, FTIR and Raman spectroscopies, demonstrating the presence of characteristic structural units. Morphological features and elemental distribution within the synthesized powder were studied by SEM/EDX analysis. XPS, EPR and magnetic studies confirmed the presence of Mn ions in a divalent state. Temperature-dependent magnetic measurements revealed a paramagnetic behavior of Mn-WH down to 5 K. In vitro cytotoxicity experiments were performed with MC3T3-E1 preosteoblastic cell line.

Original language	English
Pages (from-to)	28490-28497
Number of pages	8
Journal	Ceramics International
Volume	50
Issue number	16
DOIs	https://doi.org/10.1016/j.ceramint.2024.05.157
Publication status	Published - 15 Aug 2024

Keywords

Ca Mn (HPO ) (PO )
Cell viability
Dissolution-precipitation
Manganese whitlockite

Access to Document

10.1016/j.ceramint.2024.05.157

Cite this

Antuzevičs, A., Dubņika, A., Antuzevics, A., Dubnika, A., Dubnika, A., Goto, T., Kizalaite, A., Murauskas, T., Kizalaite, A., Zarkov, A., Murauskas, T., Stewart, O. J., Goto, T., Murauskas, T., Goto, T., Stewart, O., Stoll, S. L., Antuzevics, A., Sekino, T., ... Dubnika, A. (2024). Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite. Ceramics International, 50(16), 28490-28497. https://doi.org/10.1016/j.ceramint.2024.05.157

@article{456cefcbe9924407b3214fdc003f7424,

title = "Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite",

abstract = "In this work, manganese whitlockite (Mn-WH, Ca18Mn2(HPO4)2(PO4)12) was successfully synthesized and comprehensively characterized. This material is a manganese-containing analog of the biomineral magnesium whitlockite (Mg-WH, Ca18Mg2(HPO4)2(PO4)12). The synthesis was performed via a low-temperature dissolution-precipitation process in aqueous medium under ambient pressure at 75 °C using dicalcium phosphate dehydrate and manganese acetate tetrahydrate as starting materials. The crystal structure of the synthesized powder was determined by powder X-ray diffraction, FTIR and Raman spectroscopies, demonstrating the presence of characteristic structural units. Morphological features and elemental distribution within the synthesized powder were studied by SEM/EDX analysis. XPS, EPR and magnetic studies confirmed the presence of Mn ions in a divalent state. Temperature-dependent magnetic measurements revealed a paramagnetic behavior of Mn-WH down to 5 K. In vitro cytotoxicity experiments were performed with MC3T3-E1 preosteoblastic cell line.",

keywords = "Ca Mn (HPO ) (PO ), Cell viability, Dissolution-precipitation, Manganese whitlockite",

author = "Andris Antuzevi{\v c}s and Arita Dubņika and A Antuzevics and A. Dubnika and A Dubnika and T Goto and A Kizalaite and T. Murauskas and A. Kizalaite and A Zarkov and T Murauskas and Stewart, \{O Jr\} and T Goto and T Murauskas and T. Goto and O. Stewart and S.L. Stoll and A Antuzevics and T. Sekino and A Antuzevics and A. Zarkov and A Kizalaite and A Kizalaite and T Goto and A Kizalaite and A Zarkov and T Murauskas and A Dubnika and A Antuzevics and A Zarkov and T Murauskas and T Goto and A Zarkov and A Dubnika",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd and Techna Group S.r.l.",

year = "2024",

month = aug,

day = "15",

doi = "10.1016/j.ceramint.2024.05.157",

language = "English",

volume = "50",

pages = "28490--28497",

journal = "Ceramics International",

issn = "0272-8842",

publisher = "Elsevier Ltd",

number = "16",

}

Antuzevičs, A, Dubņika, A, Antuzevics, A, Dubnika, A, Dubnika, A, Goto, T, Kizalaite, A, Murauskas, T, Kizalaite, A, Zarkov, A, Murauskas, T, Stewart, OJ, Goto, T, Murauskas, T, Goto, T, Stewart, O, Stoll, SL, Antuzevics, A, Sekino, T, Antuzevics, A, Zarkov, A, Kizalaite, A, Kizalaite, A, Goto, T, Kizalaite, A, Zarkov, A, Murauskas, T, Dubnika, A, Antuzevics, A, Zarkov, A, Murauskas, T, Goto, T, Zarkov, A & Dubnika, A 2024, 'Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite', Ceramics International, vol. 50, no. 16, pp. 28490-28497. https://doi.org/10.1016/j.ceramint.2024.05.157

TY - JOUR

T1 - Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite

AU - Antuzevičs, Andris

AU - Dubņika, Arita

AU - Antuzevics, A

AU - Dubnika, A.

AU - Dubnika, A

AU - Goto, T

AU - Kizalaite, A

AU - Murauskas, T.

AU - Kizalaite, A.

AU - Zarkov, A

AU - Murauskas, T

AU - Stewart, O Jr

AU - Goto, T

AU - Murauskas, T

AU - Goto, T.

AU - Stewart, O.

AU - Stoll, S.L.

AU - Antuzevics, A

AU - Sekino, T.

AU - Antuzevics, A

AU - Zarkov, A.

AU - Kizalaite, A

AU - Goto, T

AU - Kizalaite, A

AU - Zarkov, A

AU - Murauskas, T

AU - Dubnika, A

AU - Antuzevics, A

AU - Zarkov, A

AU - Murauskas, T

AU - Goto, T

AU - Zarkov, A

AU - Dubnika, A

PY - 2024/8/15

Y1 - 2024/8/15

N2 - In this work, manganese whitlockite (Mn-WH, Ca18Mn2(HPO4)2(PO4)12) was successfully synthesized and comprehensively characterized. This material is a manganese-containing analog of the biomineral magnesium whitlockite (Mg-WH, Ca18Mg2(HPO4)2(PO4)12). The synthesis was performed via a low-temperature dissolution-precipitation process in aqueous medium under ambient pressure at 75 °C using dicalcium phosphate dehydrate and manganese acetate tetrahydrate as starting materials. The crystal structure of the synthesized powder was determined by powder X-ray diffraction, FTIR and Raman spectroscopies, demonstrating the presence of characteristic structural units. Morphological features and elemental distribution within the synthesized powder were studied by SEM/EDX analysis. XPS, EPR and magnetic studies confirmed the presence of Mn ions in a divalent state. Temperature-dependent magnetic measurements revealed a paramagnetic behavior of Mn-WH down to 5 K. In vitro cytotoxicity experiments were performed with MC3T3-E1 preosteoblastic cell line.

AB - In this work, manganese whitlockite (Mn-WH, Ca18Mn2(HPO4)2(PO4)12) was successfully synthesized and comprehensively characterized. This material is a manganese-containing analog of the biomineral magnesium whitlockite (Mg-WH, Ca18Mg2(HPO4)2(PO4)12). The synthesis was performed via a low-temperature dissolution-precipitation process in aqueous medium under ambient pressure at 75 °C using dicalcium phosphate dehydrate and manganese acetate tetrahydrate as starting materials. The crystal structure of the synthesized powder was determined by powder X-ray diffraction, FTIR and Raman spectroscopies, demonstrating the presence of characteristic structural units. Morphological features and elemental distribution within the synthesized powder were studied by SEM/EDX analysis. XPS, EPR and magnetic studies confirmed the presence of Mn ions in a divalent state. Temperature-dependent magnetic measurements revealed a paramagnetic behavior of Mn-WH down to 5 K. In vitro cytotoxicity experiments were performed with MC3T3-E1 preosteoblastic cell line.

KW - Ca Mn (HPO ) (PO )

KW - Cell viability

KW - Dissolution-precipitation

KW - Manganese whitlockite

UR - https://www.scopus.com/pages/publications/85192827949

U2 - 10.1016/j.ceramint.2024.05.157

DO - 10.1016/j.ceramint.2024.05.157

M3 - Article

SN - 0272-8842

VL - 50

SP - 28490

EP - 28497

JO - Ceramics International

JF - Ceramics International

IS - 16

ER -

Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite

Abstract

Keywords

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