Microwave-promoted automated synthesis of a coumarin library

M. Katkevičs; A. Kontijevskis; I. Mutule; E. Sūna

doi:10.1007/s10593-007-0025-x

Microwave-promoted automated synthesis of a coumarin library

M. Katkevičs^*
, A. Kontijevskis
, I. Mutule
, E. Sūna

^*Corresponding author for this work

Latvian Institute of Organic Synthesis

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

A 30-membered library of coumarins has been synthesized in a microwave-assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction medium. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of a specially-built microwave synthesizer with liquid handling tools rendered the automated synthesis of a coumarin library feasible.

Original language	English
Pages (from-to)	151-159
Number of pages	9
Journal	Chemistry of Heterocyclic Compounds
Volume	43
Issue number	2
DOIs	https://doi.org/10.1007/s10593-007-0025-x
Publication status	Published - Feb 2007
Externally published	Yes

Keywords

Coumarin
Library synthesis
Microwave promoted synthesis

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10.1007/s10593-007-0025-x

Cite this

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AU - Sūna, E.

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AB - A 30-membered library of coumarins has been synthesized in a microwave-assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction medium. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of a specially-built microwave synthesizer with liquid handling tools rendered the automated synthesis of a coumarin library feasible.

KW - Coumarin

KW - Library synthesis

KW - Microwave promoted synthesis

UR - https://www.scopus.com/pages/publications/34249024636

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M3 - Article

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ER -

Microwave-promoted automated synthesis of a coumarin library

Abstract

Keywords

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