Microwave promoted automated synthesis of coumarin library

M. Katkevičs; A. Kontijevskis; I. Mutule; E. Sũna

Microwave promoted automated synthesis of coumarin library

M. Katkevičs^*
, A. Kontijevskis
, I. Mutule
, E. Sũna

^*Corresponding author for this work

Latvian Institute of Organic Synthesis

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A 30-membered library of coumarins has been synthesized in a microwave assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction media. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of purpose-built microwave synthesizer with liquid handling tools rendered automated synthesis of coumarin library feasible.

Original language	English
Pages (from-to)	200-208
Number of pages	9
Journal	Khimiya Geterotsiklicheskikh Soedinenii
Issue number	2
Publication status	Published - 2007
Externally published	Yes

Keywords

Coumarin
Library synthesis
Microwave promoted synthesis

Cite this

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title = "Microwave promoted automated synthesis of coumarin library",

abstract = "A 30-membered library of coumarins has been synthesized in a microwave assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction media. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of purpose-built microwave synthesizer with liquid handling tools rendered automated synthesis of coumarin library feasible.",

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AU - Katkevičs, M.

AU - Kontijevskis, A.

AU - Mutule, I.

AU - Sũna, E.

PY - 2007

Y1 - 2007

N2 - A 30-membered library of coumarins has been synthesized in a microwave assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction media. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of purpose-built microwave synthesizer with liquid handling tools rendered automated synthesis of coumarin library feasible.

AB - A 30-membered library of coumarins has been synthesized in a microwave assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction media. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of purpose-built microwave synthesizer with liquid handling tools rendered automated synthesis of coumarin library feasible.

KW - Coumarin

KW - Library synthesis

KW - Microwave promoted synthesis

UR - https://www.scopus.com/pages/publications/34147219394

M3 - Article

AN - SCOPUS:34147219394

SN - 0132-6244

SP - 200

EP - 208

JO - Khimiya Geterotsiklicheskikh Soedinenii

JF - Khimiya Geterotsiklicheskikh Soedinenii

IS - 2

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Microwave promoted automated synthesis of coumarin library

Abstract

Keywords

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