TY - GEN
T1 - Nanostructured hemostatic sponges made from chitosan
T2 - Structural and biological evaluation
AU - Radwan-Pragłowska, J.
AU - Korniienko, V.
AU - Husak, Ye
AU - Deineka, V.
AU - Janus,
AU - Matysek, D.
AU - Holubnycha, V.
AU - Oleshko, O.
AU - Piątkowski, M.
AU - Pogorielov, M.
N1 - Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2020.
PY - 2020
Y1 - 2020
N2 - Local hemostatic agents are a necessary element of surgical work that reduces blood loss and mortality. Despite the variety of materials, there is no perfect styptic. The most promising hemostatic agents are based on biomaterials therefore they can be left in the wound. The aim of the following research was to obtain a new type of biocompatible chitosan-based agents with high hemostatic activity. The biomaterials were obtained under microwave radiation using l-aspartic acid, l-glutamic acid as crosslinking agents. Chitosan sponges showed high porosity and antioxidant activity, and also high antibacterial activity against both S. aureus and to E. coli. This material was absolutely non-toxic on cell culture and showed good hemostatic properties after interaction with blood in vitro.
AB - Local hemostatic agents are a necessary element of surgical work that reduces blood loss and mortality. Despite the variety of materials, there is no perfect styptic. The most promising hemostatic agents are based on biomaterials therefore they can be left in the wound. The aim of the following research was to obtain a new type of biocompatible chitosan-based agents with high hemostatic activity. The biomaterials were obtained under microwave radiation using l-aspartic acid, l-glutamic acid as crosslinking agents. Chitosan sponges showed high porosity and antioxidant activity, and also high antibacterial activity against both S. aureus and to E. coli. This material was absolutely non-toxic on cell culture and showed good hemostatic properties after interaction with blood in vitro.
UR - https://www.scopus.com/pages/publications/85096618398
U2 - 10.1007/978-981-15-3996-1_10
DO - 10.1007/978-981-15-3996-1_10
M3 - Conference paper
AN - SCOPUS:85096618398
SN - 9789811539954
T3 - Springer Proceedings in Physics
SP - 95
EP - 110
BT - Nanomaterials in Biomedical Application and Biosensors, NAP 2019
A2 - Pogrebnjak, Alexander D.
A2 - Pogorielov, Maksym
A2 - Viter, Roman
PB - Springer Science and Business Media Deutschland GmbH
ER -