Preparation and cytotoxic properties of goethite-based nanoparticles covered with decyldimethyl(dimethylaminoethoxy) silane methiodide

Izolda Segal; Alla Zablotskaya; Edmunds Lukevics; Mikhail Maiorov; Dmitry Zablotsky; Elmars Blums; Anatoly Mishnev; Radostina Georgieva; Irina Shestakova; Anita Gulbe

doi:10.1002/aoc.1573

Preparation and cytotoxic properties of goethite-based nanoparticles covered with decyldimethyl(dimethylaminoethoxy) silane methiodide

Izolda Segal^*
, Alla Zablotskaya
, Edmunds Lukevics
, Mikhail Maiorov
, Dmitry Zablotsky
, Elmars Blums
, Anatoly Mishnev
, Radostina Georgieva
, Irina Shestakova
, Anita Gulbe

^*Corresponding author for this work

Latvian Institute of Organic Synthesis
Charité – Universitätsmedizin Berlin

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The present work describes the synthesis, physico-chemical and biological properties of the first water-soluble goethite nanoparticles coveredwithbiologically activecomponents:oleic acidandcytotoxicdecyldimethyl(dimethylaminoethoxy)silane methiodide. The structure of initial goethite nanoparticles synthesized was proved by XRD analysis and the rough estimation of nanoparticles core size gave the value of 8 nm. The size of colloidal water-soluble nanoparticles, determined by dynamic light scattering, was within 19-35 nm. Magnetic properties and cytotoxicity (against HT-1080 and MG-22A tumor cell lines) of the nanoparticles obtained were investigated.

Original language	English
Pages (from-to)	193-197
Journal	Applied Organometallic Chemistry
Volume	24
Issue number	3
DOIs	https://doi.org/10.1002/aoc.1573
Publication status	Published - Mar 2010

OECD Field of Science

1.4 Chemical Sciences

Keywords

Choline analogs
Cytotoxicity
Drug delivery
Iron oxide nanoparticles
Organosilicon compounds

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10.1002/aoc.1573

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abstract = "The present work describes the synthesis, physico-chemical and biological properties of the first water-soluble goethite nanoparticles coveredwithbiologically activecomponents:oleic acidandcytotoxicdecyldimethyl(dimethylaminoethoxy)silane methiodide. The structure of initial goethite nanoparticles synthesized was proved by XRD analysis and the rough estimation of nanoparticles core size gave the value of 8 nm. The size of colloidal water-soluble nanoparticles, determined by dynamic light scattering, was within 19-35 nm. Magnetic properties and cytotoxicity (against HT-1080 and MG-22A tumor cell lines) of the nanoparticles obtained were investigated.",

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author = "Izolda Segal and Alla Zablotskaya and Edmunds Lukevics and Mikhail Maiorov and Dmitry Zablotsky and Elmars Blums and Anatoly Mishnev and Radostina Georgieva and Irina Shestakova and Anita Gulbe",

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T1 - Preparation and cytotoxic properties of goethite-based nanoparticles covered with decyldimethyl(dimethylaminoethoxy) silane methiodide

AU - Segal, Izolda

AU - Zablotskaya, Alla

AU - Lukevics, Edmunds

AU - Maiorov, Mikhail

AU - Zablotsky, Dmitry

AU - Blums, Elmars

AU - Mishnev, Anatoly

AU - Georgieva, Radostina

AU - Shestakova, Irina

AU - Gulbe, Anita

PY - 2010/3

Y1 - 2010/3

N2 - The present work describes the synthesis, physico-chemical and biological properties of the first water-soluble goethite nanoparticles coveredwithbiologically activecomponents:oleic acidandcytotoxicdecyldimethyl(dimethylaminoethoxy)silane methiodide. The structure of initial goethite nanoparticles synthesized was proved by XRD analysis and the rough estimation of nanoparticles core size gave the value of 8 nm. The size of colloidal water-soluble nanoparticles, determined by dynamic light scattering, was within 19-35 nm. Magnetic properties and cytotoxicity (against HT-1080 and MG-22A tumor cell lines) of the nanoparticles obtained were investigated.

AB - The present work describes the synthesis, physico-chemical and biological properties of the first water-soluble goethite nanoparticles coveredwithbiologically activecomponents:oleic acidandcytotoxicdecyldimethyl(dimethylaminoethoxy)silane methiodide. The structure of initial goethite nanoparticles synthesized was proved by XRD analysis and the rough estimation of nanoparticles core size gave the value of 8 nm. The size of colloidal water-soluble nanoparticles, determined by dynamic light scattering, was within 19-35 nm. Magnetic properties and cytotoxicity (against HT-1080 and MG-22A tumor cell lines) of the nanoparticles obtained were investigated.

KW - Choline analogs

KW - Cytotoxicity

KW - Drug delivery

KW - Iron oxide nanoparticles

KW - Organosilicon compounds

UR - https://www.scopus.com/pages/publications/77449141856

U2 - 10.1002/aoc.1573

DO - 10.1002/aoc.1573

M3 - Article

AN - SCOPUS:77449141856

SN - 0268-2605

VL - 24

SP - 193

EP - 197

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

IS - 3

ER -

Preparation and cytotoxic properties of goethite-based nanoparticles covered with decyldimethyl(dimethylaminoethoxy) silane methiodide

Abstract

OECD Field of Science

Keywords

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