Risk Factors of Premature Atherosclerotic Cardiovascular Disease in China: A Longitudinal Analysis of the China Health and Nutrition Survey Cohort

Yihong Ding; Yifan Zhou; Hui Han; Chen Chen; Yelena Tarasenko

doi:10.1177/10105395241226525

Risk Factors of Premature Atherosclerotic Cardiovascular Disease in China: A Longitudinal Analysis of the China Health and Nutrition Survey Cohort

Yihong Ding
, Yifan Zhou
, Hui Han
, Chen Chen^*
, Yelena Tarasenko

^*Corresponding author for this work

Zhejiang University
Georgia Southern University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The burden of premature atherosclerotic cardiovascular disease (ASCVD) has increased rapidly in China. Using the China Health and Nutrition Survey (CHNS) data, we assessed the risk factors of premature ASCVD (age of diagnosis: <55 years for men and <65 years for women). Propensity score matching was used to reduce selection bias. Multivariable Cox proportional-hazards analyses indicated that factors associated with increased risk of premature ASCVD included hypertension (adjusted hazard ratio [HR_adj.] = 1.68), obesity (HR_adj. = 1.64), and high carbohydrate intake (HR_adj. = 1.46). Conversely, participants with medical insurance (HR_adj. = 0.42), high urbanization index (HR_adj. = 0.53), and high household income (HR_adj. = 0.48) had lower risk of premature ASCVD. When comparing premature vs non-premature ASCVD participants, those who were obese (HR_adj. = 2.08) or living in more urbanized areas had higher hazards of early onset (HR_adj. = 2.29).

Original language	English
Pages (from-to)	192-201
Number of pages	10
Journal	Asia-Pacific Journal of Public Health
Volume	36
Issue number	2-3
DOIs	https://doi.org/10.1177/10105395241226525
Publication status	Published - Mar 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

China Health and Nutrition Survey
cohort study
early onset
premature atherosclerotic cardiovascular disease
risk factors

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10.1177/10105395241226525

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@article{045dc33e3398432396a052fd73991a54,

title = "Risk Factors of Premature Atherosclerotic Cardiovascular Disease in China: A Longitudinal Analysis of the China Health and Nutrition Survey Cohort",

abstract = "The burden of premature atherosclerotic cardiovascular disease (ASCVD) has increased rapidly in China. Using the China Health and Nutrition Survey (CHNS) data, we assessed the risk factors of premature ASCVD (age of diagnosis: <55 years for men and <65 years for women). Propensity score matching was used to reduce selection bias. Multivariable Cox proportional-hazards analyses indicated that factors associated with increased risk of premature ASCVD included hypertension (adjusted hazard ratio [HRadj.] = 1.68), obesity (HRadj. = 1.64), and high carbohydrate intake (HRadj. = 1.46). Conversely, participants with medical insurance (HRadj. = 0.42), high urbanization index (HRadj. = 0.53), and high household income (HRadj. = 0.48) had lower risk of premature ASCVD. When comparing premature vs non-premature ASCVD participants, those who were obese (HRadj. = 2.08) or living in more urbanized areas had higher hazards of early onset (HRadj. = 2.29).",

keywords = "China Health and Nutrition Survey, cohort study, early onset, premature atherosclerotic cardiovascular disease, risk factors",

author = "Yihong Ding and Yifan Zhou and Hui Han and Chen Chen and Yelena Tarasenko",

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year = "2024",

month = mar,

doi = "10.1177/10105395241226525",

language = "English",

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pages = "192--201",

journal = "Asia-Pacific Journal of Public Health",

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TY - JOUR

T1 - Risk Factors of Premature Atherosclerotic Cardiovascular Disease in China

T2 - A Longitudinal Analysis of the China Health and Nutrition Survey Cohort

AU - Ding, Yihong

AU - Zhou, Yifan

AU - Han, Hui

AU - Chen, Chen

AU - Tarasenko, Yelena

PY - 2024/3

Y1 - 2024/3

N2 - The burden of premature atherosclerotic cardiovascular disease (ASCVD) has increased rapidly in China. Using the China Health and Nutrition Survey (CHNS) data, we assessed the risk factors of premature ASCVD (age of diagnosis: <55 years for men and <65 years for women). Propensity score matching was used to reduce selection bias. Multivariable Cox proportional-hazards analyses indicated that factors associated with increased risk of premature ASCVD included hypertension (adjusted hazard ratio [HRadj.] = 1.68), obesity (HRadj. = 1.64), and high carbohydrate intake (HRadj. = 1.46). Conversely, participants with medical insurance (HRadj. = 0.42), high urbanization index (HRadj. = 0.53), and high household income (HRadj. = 0.48) had lower risk of premature ASCVD. When comparing premature vs non-premature ASCVD participants, those who were obese (HRadj. = 2.08) or living in more urbanized areas had higher hazards of early onset (HRadj. = 2.29).

AB - The burden of premature atherosclerotic cardiovascular disease (ASCVD) has increased rapidly in China. Using the China Health and Nutrition Survey (CHNS) data, we assessed the risk factors of premature ASCVD (age of diagnosis: <55 years for men and <65 years for women). Propensity score matching was used to reduce selection bias. Multivariable Cox proportional-hazards analyses indicated that factors associated with increased risk of premature ASCVD included hypertension (adjusted hazard ratio [HRadj.] = 1.68), obesity (HRadj. = 1.64), and high carbohydrate intake (HRadj. = 1.46). Conversely, participants with medical insurance (HRadj. = 0.42), high urbanization index (HRadj. = 0.53), and high household income (HRadj. = 0.48) had lower risk of premature ASCVD. When comparing premature vs non-premature ASCVD participants, those who were obese (HRadj. = 2.08) or living in more urbanized areas had higher hazards of early onset (HRadj. = 2.29).

KW - China Health and Nutrition Survey

KW - cohort study

KW - early onset

KW - premature atherosclerotic cardiovascular disease

KW - risk factors

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U2 - 10.1177/10105395241226525

DO - 10.1177/10105395241226525

M3 - Article

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AN - SCOPUS:85182804901

SN - 1010-5395

VL - 36

SP - 192

EP - 201

JO - Asia-Pacific Journal of Public Health

JF - Asia-Pacific Journal of Public Health

IS - 2-3

ER -

Risk Factors of Premature Atherosclerotic Cardiovascular Disease in China: A Longitudinal Analysis of the China Health and Nutrition Survey Cohort

Abstract

UN SDGs

Keywords

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