Role of abca7 in human health and in alzheimer’s disease

Shiraz Dib; Jens Pahnke; Fabien Gosselet

doi:10.3390/ijms22094603

Role of abca7 in human health and in alzheimer’s disease

Shiraz Dib
, Jens Pahnke
, Fabien Gosselet^*

^*Corresponding author for this work

Department of Neuromedicine and Neuroscience

Université d'Artois
Leibniz Institute of Plant Biochemistry
University of Lübeck
University of Oslo

Research output: Contribution to journal › Review article › peer-review

70 Citations (Scopus)

Abstract

Several studies, including genome wide association studies (GWAS), have strongly sug-gested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic deter-minant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.

Original language	English
Article number	4603
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	9
DOIs	https://doi.org/10.3390/ijms22094603
Publication status	Published - 1 May 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ABCA7
Alzheimer’s disease
Aβ peptides
Cholesterol
Phagocytosis

OECD Field of Science

3. Medical and Health Sciences

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10.3390/ijms22094603

Cite this

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title = "Role of abca7 in human health and in alzheimer{\textquoteright}s disease",

abstract = "Several studies, including genome wide association studies (GWAS), have strongly sug-gested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer{\textquoteright}s disease (AD). This ABC transporter is now considered as an important genetic deter-minant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.",

keywords = "ABCA7, Alzheimer{\textquoteright}s disease, Aβ peptides, Cholesterol, Phagocytosis",

author = "Shiraz Dib and Jens Pahnke and Fabien Gosselet",

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year = "2021",

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language = "English",

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T1 - Role of abca7 in human health and in alzheimer’s disease

AU - Dib, Shiraz

AU - Pahnke, Jens

AU - Gosselet, Fabien

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Several studies, including genome wide association studies (GWAS), have strongly sug-gested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic deter-minant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.

AB - Several studies, including genome wide association studies (GWAS), have strongly sug-gested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic deter-minant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.

KW - ABCA7

KW - Alzheimer’s disease

KW - Aβ peptides

KW - Cholesterol

KW - Phagocytosis

UR - https://www.mdpi.com/1422-0067/22/9/4603

UR - https://www.scopus.com/pages/publications/85104721017

U2 - 10.3390/ijms22094603

DO - 10.3390/ijms22094603

M3 - Review article

C2 - 33925691

SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 9

M1 - 4603

ER -

Role of abca7 in human health and in alzheimer’s disease

Abstract

UN SDGs

Keywords

OECD Field of Science

Access to Document

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