Role of the ubiquitin-proteasome protein degradation pathway in carcinogenesis, tumor progression and susceptibility to tumor treatment

N. Sjakste; T. Sjakste; U. Vikmanis

Role of the ubiquitin-proteasome protein degradation pathway in carcinogenesis, tumor progression and susceptibility to tumor treatment

N. Sjakste^*
, T. Sjakste
, U. Vikmanis

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

The review summarizes data on involvement of the proteasomes and other enzymes performing the ubiquitin-mediated proteolysis in carcinogenesis, tumor biology and mechanisms of action of antitumor drugs. Increased or decreased susceptibility of oncoproteins and tumor suppressors can give rise to tumorigenesis. Proteasome composition and proteasome activity is altered in neoplastic cells. Novel antitumor drugs can be developed from the proteasome inhibitors.

Original language	English
Pages (from-to)	243-248
Number of pages	6
Journal	Experimental Oncology
Volume	24
Issue number	4
Publication status	Published - Dec 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Proteasomes

Cite this

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title = "Role of the ubiquitin-proteasome protein degradation pathway in carcinogenesis, tumor progression and susceptibility to tumor treatment",

abstract = "The review summarizes data on involvement of the proteasomes and other enzymes performing the ubiquitin-mediated proteolysis in carcinogenesis, tumor biology and mechanisms of action of antitumor drugs. Increased or decreased susceptibility of oncoproteins and tumor suppressors can give rise to tumorigenesis. Proteasome composition and proteasome activity is altered in neoplastic cells. Novel antitumor drugs can be developed from the proteasome inhibitors.",

keywords = "Cancer, Proteasomes",

author = "N. Sjakste and T. Sjakste and U. Vikmanis",

year = "2002",

month = dec,

language = "English",

volume = "24",

pages = "243--248",

journal = "Experimental Oncology",

issn = "1812-9269",

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TY - JOUR

T1 - Role of the ubiquitin-proteasome protein degradation pathway in carcinogenesis, tumor progression and susceptibility to tumor treatment

AU - Sjakste, N.

AU - Sjakste, T.

AU - Vikmanis, U.

PY - 2002/12

Y1 - 2002/12

N2 - The review summarizes data on involvement of the proteasomes and other enzymes performing the ubiquitin-mediated proteolysis in carcinogenesis, tumor biology and mechanisms of action of antitumor drugs. Increased or decreased susceptibility of oncoproteins and tumor suppressors can give rise to tumorigenesis. Proteasome composition and proteasome activity is altered in neoplastic cells. Novel antitumor drugs can be developed from the proteasome inhibitors.

AB - The review summarizes data on involvement of the proteasomes and other enzymes performing the ubiquitin-mediated proteolysis in carcinogenesis, tumor biology and mechanisms of action of antitumor drugs. Increased or decreased susceptibility of oncoproteins and tumor suppressors can give rise to tumorigenesis. Proteasome composition and proteasome activity is altered in neoplastic cells. Novel antitumor drugs can be developed from the proteasome inhibitors.

KW - Cancer

KW - Proteasomes

UR - https://www.scopus.com/pages/publications/0036971557

M3 - Review article

AN - SCOPUS:0036971557

SN - 1812-9269

VL - 24

SP - 243

EP - 248

JO - Experimental Oncology

JF - Experimental Oncology

IS - 4

ER -

Role of the ubiquitin-proteasome protein degradation pathway in carcinogenesis, tumor progression and susceptibility to tumor treatment

Abstract

UN SDGs

Keywords

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