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Studies of preparation and stability of liposomes formed by 1,1'-[(3,5-didodeciloxycarbonyl-4-phenyl-1,4-dihydropyridine-2,6-diil)-di methylen]bispyridinium Dibromide

  • Martins Rucins
  • , Oksana Petricenko
  • , Karlis Pajuste
  • , Mara Plotniece
  • , Klavs Pajuste
  • , Marina Gosteva
  • , Brigita Cekavicus
  • , Arkadij Sobolev
  • , Aiva Plotniece
  • Latvian Institute of Organic Synthesis

Research output: Chapter in Book/Report/Conference proceedingConference paperResearchpeer-review

1 Citation (Scopus)

Abstract

In this work we describe the studies of preparation and stability of liposomes formed by 1,1'-[(3,5-didodeciloxycarbonyl-4-phenyl-1,4-dihydropyridine-2,6-diil)dimethylen]bispyridinium dibromide, novel lipid-like compound. The influence of the amount of amphiphilic compound, solvent and sonication time was studied. Liposomes were prepared by dispersing of compound in the corresponding media at a selected concentration by sonication using a probe type sonicator and characterised by atomic force microscopy (AFM) and dynamic light scattering (DLS) methods.

Original languageEnglish
Title of host publicationAdvanced Materials Researches, Engineering and Manufacturing Technologies in Industry
Pages157-162
Number of pages6
DOIs
Publication statusPublished - 2013
Event2013 2nd International Symposium on Materials Science and Engineering Technology, ISMSET 2013 - Guangzhou, China
Duration: 27 Jun 201328 Jun 2013

Publication series

NameAdvanced Materials Research
Volume787
ISSN (Print)1022-6680

Conference

Conference2013 2nd International Symposium on Materials Science and Engineering Technology, ISMSET 2013
Country/TerritoryChina
CityGuangzhou
Period27/06/1328/06/13

Keywords

  • 1,4-dihydropyridine amphiphile
  • AFM
  • DLS
  • Gene delivery
  • Liposomes
  • Self-assembling

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