Synthesis and characterization of nanoparticles with an iron oxide magnetic core and a biologically active trialkylsilylated aliphatic alkanolamine shell

Alla Zablotskaya; Izolda Segal; Mikhail Maiorov; Dmitry Zablotsky; Anatoly Mishnev; Edmunds Lukevics; Irina Shestakova; Ilona Domracheva

doi:10.1016/j.jmmm.2006.11.176

Synthesis and characterization of nanoparticles with an iron oxide magnetic core and a biologically active trialkylsilylated aliphatic alkanolamine shell

Alla Zablotskaya^*
, Izolda Segal
, Mikhail Maiorov
, Dmitry Zablotsky
, Anatoly Mishnev
, Edmunds Lukevics
, Irina Shestakova
, Ilona Domracheva

^*Corresponding author for this work

Institute of Physics

Latvian Institute of Organic Synthesis

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Water-soluble double-coated magnetic nanoparticles (NPs) containing cytotoxic decyldimethyl(β-dimethylaminoethoxy)silane methiodide (AA) molecule sorbed at biocompatible magnetic particles, which consist of magnetite pre-coated with oleic acid (OA), have been prepared. X-ray line profile broadening analysis was used for crystallite size determination. The method of magnetogranulometry has been used for determination of diameter of iron oxide magnetic core and magnetic properties of NPs prepared. In vitro cytotoxicity on monolayer tumor cell lines HT-1080 (human fibrosarcoma), MG-22A (mouse hepatoma) and normal mouse fibroblasts (NIH 3T3) has been studied. It was revealed that all the water-based colloidal solutions obtained are non-toxic and possess high NO-induction ability.

Original language	English
Pages (from-to)	135-139
Number of pages	5
Journal	Journal of Magnetism and Magnetic Materials
Volume	311
Issue number	1 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.jmmm.2006.11.176
Publication status	Published - Apr 2007

Keywords

Alkanolamines
Cytotoxicity
Iron oxide
Magnetic nanoparticles
Magnetoliposomes
Organosilicon

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10.1016/j.jmmm.2006.11.176

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Zablotskaya, A., Segal, I., Maiorov, M., Zablotsky, D., Mishnev, A., Lukevics, E., Shestakova, I., & Domracheva, I. (2007). Synthesis and characterization of nanoparticles with an iron oxide magnetic core and a biologically active trialkylsilylated aliphatic alkanolamine shell. Journal of Magnetism and Magnetic Materials, 311(1 SPEC. ISS.), 135-139. https://doi.org/10.1016/j.jmmm.2006.11.176

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title = "Synthesis and characterization of nanoparticles with an iron oxide magnetic core and a biologically active trialkylsilylated aliphatic alkanolamine shell",

abstract = "Water-soluble double-coated magnetic nanoparticles (NPs) containing cytotoxic decyldimethyl(β-dimethylaminoethoxy)silane methiodide (AA) molecule sorbed at biocompatible magnetic particles, which consist of magnetite pre-coated with oleic acid (OA), have been prepared. X-ray line profile broadening analysis was used for crystallite size determination. The method of magnetogranulometry has been used for determination of diameter of iron oxide magnetic core and magnetic properties of NPs prepared. In vitro cytotoxicity on monolayer tumor cell lines HT-1080 (human fibrosarcoma), MG-22A (mouse hepatoma) and normal mouse fibroblasts (NIH 3T3) has been studied. It was revealed that all the water-based colloidal solutions obtained are non-toxic and possess high NO-induction ability.",

keywords = "Alkanolamines, Cytotoxicity, Iron oxide, Magnetic nanoparticles, Magnetoliposomes, Organosilicon",

author = "Alla Zablotskaya and Izolda Segal and Mikhail Maiorov and Dmitry Zablotsky and Anatoly Mishnev and Edmunds Lukevics and Irina Shestakova and Ilona Domracheva",

year = "2007",

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language = "English",

volume = "311",

pages = "135--139",

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Zablotskaya, A, Segal, I, Maiorov, M , Zablotsky, D, Mishnev, A, Lukevics, E, Shestakova, I & Domracheva, I 2007, 'Synthesis and characterization of nanoparticles with an iron oxide magnetic core and a biologically active trialkylsilylated aliphatic alkanolamine shell', Journal of Magnetism and Magnetic Materials, vol. 311, no. 1 SPEC. ISS., pp. 135-139. https://doi.org/10.1016/j.jmmm.2006.11.176

Synthesis and characterization of nanoparticles with an iron oxide magnetic core and a biologically active trialkylsilylated aliphatic alkanolamine shell. / Zablotskaya, Alla; Segal, Izolda; Maiorov, Mikhail et al.
In: Journal of Magnetism and Magnetic Materials, Vol. 311, No. 1 SPEC. ISS., 04.2007, p. 135-139.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis and characterization of nanoparticles with an iron oxide magnetic core and a biologically active trialkylsilylated aliphatic alkanolamine shell

AU - Zablotskaya, Alla

AU - Segal, Izolda

AU - Maiorov, Mikhail

AU - Zablotsky, Dmitry

AU - Mishnev, Anatoly

AU - Lukevics, Edmunds

AU - Shestakova, Irina

AU - Domracheva, Ilona

PY - 2007/4

Y1 - 2007/4

N2 - Water-soluble double-coated magnetic nanoparticles (NPs) containing cytotoxic decyldimethyl(β-dimethylaminoethoxy)silane methiodide (AA) molecule sorbed at biocompatible magnetic particles, which consist of magnetite pre-coated with oleic acid (OA), have been prepared. X-ray line profile broadening analysis was used for crystallite size determination. The method of magnetogranulometry has been used for determination of diameter of iron oxide magnetic core and magnetic properties of NPs prepared. In vitro cytotoxicity on monolayer tumor cell lines HT-1080 (human fibrosarcoma), MG-22A (mouse hepatoma) and normal mouse fibroblasts (NIH 3T3) has been studied. It was revealed that all the water-based colloidal solutions obtained are non-toxic and possess high NO-induction ability.

AB - Water-soluble double-coated magnetic nanoparticles (NPs) containing cytotoxic decyldimethyl(β-dimethylaminoethoxy)silane methiodide (AA) molecule sorbed at biocompatible magnetic particles, which consist of magnetite pre-coated with oleic acid (OA), have been prepared. X-ray line profile broadening analysis was used for crystallite size determination. The method of magnetogranulometry has been used for determination of diameter of iron oxide magnetic core and magnetic properties of NPs prepared. In vitro cytotoxicity on monolayer tumor cell lines HT-1080 (human fibrosarcoma), MG-22A (mouse hepatoma) and normal mouse fibroblasts (NIH 3T3) has been studied. It was revealed that all the water-based colloidal solutions obtained are non-toxic and possess high NO-induction ability.

KW - Alkanolamines

KW - Cytotoxicity

KW - Iron oxide

KW - Magnetic nanoparticles

KW - Magnetoliposomes

KW - Organosilicon

UR - https://www.scopus.com/pages/publications/33947241913

U2 - 10.1016/j.jmmm.2006.11.176

DO - 10.1016/j.jmmm.2006.11.176

M3 - Article

AN - SCOPUS:33947241913

SN - 0304-8853

VL - 311

SP - 135

EP - 139

JO - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

IS - 1 SPEC. ISS.

ER -

Synthesis and characterization of nanoparticles with an iron oxide magnetic core and a biologically active trialkylsilylated aliphatic alkanolamine shell

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