Synthesis, physico-chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer

Izolda Segal; Alla Zablotskaya; Edmunds Lukevics; Mikhail Maiorov; Dmitry Zablotsky; Elmars Blums; Irina Shestakova; Ilona Domracheva

doi:10.1002/aoc.1354

Synthesis, physico-chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer

Izolda Segal^*
, Alla Zablotskaya
, Edmunds Lukevics
, Mikhail Maiorov
, Dmitry Zablotsky
, Elmars Blums
, Irina Shestakova
, Ilona Domracheva

^*Corresponding author for this work

Latvian Institute of Organic Synthesis

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

New original water-soluble magnetic nanoparticles based on natural components, magnetite-oleic acid-biologically active silyl modified alkanolamine, were synthesized. Physico-chemical characterization, i.e. magnetic properties, concentration of magnetite, size of iron oxide core, of the nanoparticles synthesized and the corresponding magnetic fluids obtained, was carried out. Magnetic fluids were screened for in vitro cytotoxicity concerning human fibrosarcoma (HT-1080), mouse hepatoma (MG-22A) monolayer tumour cell lines and normal mouse fibroblasts (NIH 3T3). They possess low or moderate cytotoxic effects, are non-toxic, exhibit high NO-induction ability and strongly change tumour cell morphology.

Original language	English
Pages (from-to)	82-88
Number of pages	7
Journal	Applied Organometallic Chemistry
Volume	22
Issue number	2
DOIs	https://doi.org/10.1002/aoc.1354
Publication status	Published - Feb 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alkanolamines
Cytotoxicity
Drug research
Iron oxide
Magnetic fluids
Magnetosomes
Nanoparticles
Organosilicon compounds

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10.1002/aoc.1354

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title = "Synthesis, physico-chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer",

abstract = "New original water-soluble magnetic nanoparticles based on natural components, magnetite-oleic acid-biologically active silyl modified alkanolamine, were synthesized. Physico-chemical characterization, i.e. magnetic properties, concentration of magnetite, size of iron oxide core, of the nanoparticles synthesized and the corresponding magnetic fluids obtained, was carried out. Magnetic fluids were screened for in vitro cytotoxicity concerning human fibrosarcoma (HT-1080), mouse hepatoma (MG-22A) monolayer tumour cell lines and normal mouse fibroblasts (NIH 3T3). They possess low or moderate cytotoxic effects, are non-toxic, exhibit high NO-induction ability and strongly change tumour cell morphology.",

keywords = "Alkanolamines, Cytotoxicity, Drug research, Iron oxide, Magnetic fluids, Magnetosomes, Nanoparticles, Organosilicon compounds",

author = "Izolda Segal and Alla Zablotskaya and Edmunds Lukevics and Mikhail Maiorov and Dmitry Zablotsky and Elmars Blums and Irina Shestakova and Ilona Domracheva",

year = "2008",

month = feb,

doi = "10.1002/aoc.1354",

language = "English",

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journal = "Applied Organometallic Chemistry",

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TY - JOUR

T1 - Synthesis, physico-chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer

AU - Segal, Izolda

AU - Zablotskaya, Alla

AU - Lukevics, Edmunds

AU - Maiorov, Mikhail

AU - Zablotsky, Dmitry

AU - Blums, Elmars

AU - Shestakova, Irina

AU - Domracheva, Ilona

PY - 2008/2

Y1 - 2008/2

N2 - New original water-soluble magnetic nanoparticles based on natural components, magnetite-oleic acid-biologically active silyl modified alkanolamine, were synthesized. Physico-chemical characterization, i.e. magnetic properties, concentration of magnetite, size of iron oxide core, of the nanoparticles synthesized and the corresponding magnetic fluids obtained, was carried out. Magnetic fluids were screened for in vitro cytotoxicity concerning human fibrosarcoma (HT-1080), mouse hepatoma (MG-22A) monolayer tumour cell lines and normal mouse fibroblasts (NIH 3T3). They possess low or moderate cytotoxic effects, are non-toxic, exhibit high NO-induction ability and strongly change tumour cell morphology.

AB - New original water-soluble magnetic nanoparticles based on natural components, magnetite-oleic acid-biologically active silyl modified alkanolamine, were synthesized. Physico-chemical characterization, i.e. magnetic properties, concentration of magnetite, size of iron oxide core, of the nanoparticles synthesized and the corresponding magnetic fluids obtained, was carried out. Magnetic fluids were screened for in vitro cytotoxicity concerning human fibrosarcoma (HT-1080), mouse hepatoma (MG-22A) monolayer tumour cell lines and normal mouse fibroblasts (NIH 3T3). They possess low or moderate cytotoxic effects, are non-toxic, exhibit high NO-induction ability and strongly change tumour cell morphology.

KW - Alkanolamines

KW - Cytotoxicity

KW - Drug research

KW - Iron oxide

KW - Magnetic fluids

KW - Magnetosomes

KW - Nanoparticles

KW - Organosilicon compounds

UR - https://www.scopus.com/pages/publications/40749134166

U2 - 10.1002/aoc.1354

DO - 10.1002/aoc.1354

M3 - Article

AN - SCOPUS:40749134166

SN - 0268-2605

VL - 22

SP - 82

EP - 88

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

IS - 2

ER -

Synthesis, physico-chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer

Abstract

UN SDGs

Keywords

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