The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohydrate metabolism in hyperthyroid and hypothyroid rats

E. M. Sharipova; E. V. Salna; M. Ya Dzintare; L. Ya Lauberte; D. V. Meirena; N. I. Sjakste; V. S. Gordjushina; I. Kalvinsh

doi:10.1134/S1990750808020078

The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohydrate metabolism in hyperthyroid and hypothyroid rats

E. M. Sharipova
, E. V. Salna
, M. Ya Dzintare
, L. Ya Lauberte
, D. V. Meirena
, N. I. Sjakste^*
, V. S. Gordjushina
, I. Kalvinsh

^*Corresponding author for this work

Department of Pharmaceutical Sciences

Latvian Institute of Organic Synthesis
University of Latvia

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The effects of mildronate [3(2,2,2-trimethylhydrazinium) propionate dihydrate], γ-butyrobetaine (GBB) and their combination (neomildronate) on the level of thyroid hormones and some intermediates of basal metabolism (free fatty acids, triglycerides, glucose) in serum of laboratory rats with various dysfunctions of thyroid glands including idiopathic hyperfunction and also hypofunction induced by administration of 6-propyl-2-thiouracil (PTU) or L-carnitine administration. Intraperitoneal injections of mildronate (150 mg/kg) during 20 days to male Wistar rats with elevated level of thyroid hormones and basal metabolism normalized thyroxin level and parameters of lipid metabolism in serum. Administration of the compounds studied to rats with hypothyroidism induced by administration of PTU or L-carnitine did not influence natural recovery of the hormonal level. Possible biochemical role of these pharmacological treatments is discussed in terms of in regulation of thyroid gland function.

Original language	English
Pages (from-to)	169-175
Number of pages	7
Journal	Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Volume	2
Issue number	2
DOIs	https://doi.org/10.1134/S1990750808020078
Publication status	Published - Jun 2008

Keywords

Experimental models
Intermediates of basal metabolism in blood serum
Mildronate and its derivatives
Rat thyroid gland dysfunction
Thyroid hormones

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10.1134/S1990750808020078

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Sharipova, E. M., Salna, E. V., Dzintare, M. Y., Lauberte, L. Y., Meirena, D. V., Sjakste, N. I., Gordjushina, V. S., & Kalvinsh, I. (2008). The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohydrate metabolism in hyperthyroid and hypothyroid rats. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2(2), 169-175. https://doi.org/10.1134/S1990750808020078

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title = "The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohydrate metabolism in hyperthyroid and hypothyroid rats",

abstract = "The effects of mildronate [3(2,2,2-trimethylhydrazinium) propionate dihydrate], γ-butyrobetaine (GBB) and their combination (neomildronate) on the level of thyroid hormones and some intermediates of basal metabolism (free fatty acids, triglycerides, glucose) in serum of laboratory rats with various dysfunctions of thyroid glands including idiopathic hyperfunction and also hypofunction induced by administration of 6-propyl-2-thiouracil (PTU) or L-carnitine administration. Intraperitoneal injections of mildronate (150 mg/kg) during 20 days to male Wistar rats with elevated level of thyroid hormones and basal metabolism normalized thyroxin level and parameters of lipid metabolism in serum. Administration of the compounds studied to rats with hypothyroidism induced by administration of PTU or L-carnitine did not influence natural recovery of the hormonal level. Possible biochemical role of these pharmacological treatments is discussed in terms of in regulation of thyroid gland function.",

keywords = "Experimental models, Intermediates of basal metabolism in blood serum, Mildronate and its derivatives, Rat thyroid gland dysfunction, Thyroid hormones",

author = "Sharipova, \{E. M.\} and Salna, \{E. V.\} and Dzintare, \{M. Ya\} and Lauberte, \{L. Ya\} and Meirena, \{D. V.\} and Sjakste, \{N. I.\} and Gordjushina, \{V. S.\} and I. Kalvinsh",

year = "2008",

month = jun,

doi = "10.1134/S1990750808020078",

language = "English",

volume = "2",

pages = "169--175",

journal = "Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry",

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Sharipova, EM, Salna, EV, Dzintare, MY, Lauberte, LY, Meirena, DV, Sjakste, NI, Gordjushina, VS & Kalvinsh, I 2008, 'The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohydrate metabolism in hyperthyroid and hypothyroid rats', Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, vol. 2, no. 2, pp. 169-175. https://doi.org/10.1134/S1990750808020078

The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohydrate metabolism in hyperthyroid and hypothyroid rats. / Sharipova, E. M.; Salna, E. V.; Dzintare, M. Ya et al.
In: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, Vol. 2, No. 2, 06.2008, p. 169-175.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Sharipova, E. M.

AU - Salna, E. V.

AU - Dzintare, M. Ya

AU - Lauberte, L. Ya

AU - Meirena, D. V.

AU - Sjakste, N. I.

AU - Gordjushina, V. S.

AU - Kalvinsh, I.

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N2 - The effects of mildronate [3(2,2,2-trimethylhydrazinium) propionate dihydrate], γ-butyrobetaine (GBB) and their combination (neomildronate) on the level of thyroid hormones and some intermediates of basal metabolism (free fatty acids, triglycerides, glucose) in serum of laboratory rats with various dysfunctions of thyroid glands including idiopathic hyperfunction and also hypofunction induced by administration of 6-propyl-2-thiouracil (PTU) or L-carnitine administration. Intraperitoneal injections of mildronate (150 mg/kg) during 20 days to male Wistar rats with elevated level of thyroid hormones and basal metabolism normalized thyroxin level and parameters of lipid metabolism in serum. Administration of the compounds studied to rats with hypothyroidism induced by administration of PTU or L-carnitine did not influence natural recovery of the hormonal level. Possible biochemical role of these pharmacological treatments is discussed in terms of in regulation of thyroid gland function.

AB - The effects of mildronate [3(2,2,2-trimethylhydrazinium) propionate dihydrate], γ-butyrobetaine (GBB) and their combination (neomildronate) on the level of thyroid hormones and some intermediates of basal metabolism (free fatty acids, triglycerides, glucose) in serum of laboratory rats with various dysfunctions of thyroid glands including idiopathic hyperfunction and also hypofunction induced by administration of 6-propyl-2-thiouracil (PTU) or L-carnitine administration. Intraperitoneal injections of mildronate (150 mg/kg) during 20 days to male Wistar rats with elevated level of thyroid hormones and basal metabolism normalized thyroxin level and parameters of lipid metabolism in serum. Administration of the compounds studied to rats with hypothyroidism induced by administration of PTU or L-carnitine did not influence natural recovery of the hormonal level. Possible biochemical role of these pharmacological treatments is discussed in terms of in regulation of thyroid gland function.

KW - Experimental models

KW - Intermediates of basal metabolism in blood serum

KW - Mildronate and its derivatives

KW - Rat thyroid gland dysfunction

KW - Thyroid hormones

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DO - 10.1134/S1990750808020078

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EP - 175

JO - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

JF - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

IS - 2

ER -

Sharipova EM, Salna EV, Dzintare MY, Lauberte LY, Meirena DV, Sjakste NI et al. The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohydrate metabolism in hyperthyroid and hypothyroid rats. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2008 Jun;2(2):169-175. doi: 10.1134/S1990750808020078

The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohydrate metabolism in hyperthyroid and hypothyroid rats

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