TY - JOUR
T1 - The expanded Global Registry of Acute Coronary Events
T2 - Baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes
AU - the Expanded Global Registry of Acute Coronary Events (GRACE) Investigators
AU - Goodman, Shaun G.
AU - Huang, Wei
AU - Yan, Andrew T.
AU - Budaj, Andrzej
AU - Kennelly, Brian M.
AU - Gore, Joel M.
AU - Fox, Keith A.A.
AU - Goldberg, Robert J.
AU - Anderson, Frederick A.
AU - Gurfinkel, Enrique
AU - Duronto, Ernesto
AU - Caridi, Maria
AU - Marinesco, Adolfo
AU - Luna, Maria Alejandra
AU - Bruno, Marcos Litvak
AU - Torres, Hugo
AU - de la Hoz, Ricardo Perez
AU - Brito, Viviana
AU - Beck, Edgardo
AU - Litvak-Bruno, Marcos
AU - Campo, Aníbal
AU - Maccagno, Guillermo
AU - Santopinto, José
AU - Budassi, Nadia
AU - Valle, Marisol
AU - Sosa-Liprandi, Álvaro
AU - Pellegrini, Carlos
AU - Brieger, David
AU - Aliprandi-Costa, Bernadette
AU - Brazete, Susana
AU - Brosnan, Annette
AU - Hall, Jodie Fleming Judith
AU - Heagerty, Emma
AU - McGarity, Bruce
AU - Corliss, Jackie
AU - Colwell, Tonia
AU - KellyLangdon,
AU - Beattie, Karen
AU - Davis, Paul
AU - Donnell, Jo
AU - Waites, Jon
AU - Keays, Pauline
AU - Bowen, Sheryl
AU - Cahill, Pauline
AU - Juergens, Craig
AU - Gavigan, Sue Anne
AU - Pickard, Kelly
AU - Lefkovits, Jeffrey
AU - Ruane, Susan
AU - Erglis, Andrejs
PY - 2009/8
Y1 - 2009/8
N2 - Background: The Global Registry of Acute Coronary Events (GRACE)-a prospective, multinational study of patients hospitalized with acute coronary syndromes (ACSs)-was designed to improve the quality of care for patients with an ACS. Expanded GRACE aims to test the feasibility of a simplified data collection tool and provision of quarterly feedback to index individual hospital management practices to an international reference cohort. Methods: We describe the objectives; study design; study and data management; and the characteristics, management, and hospital outcomes of patients ≥18 years old enrolled with a presumptive diagnosis of ACS. Results: From 2001 to 2007, 31,982 patients were enrolled at 184 hospitals in 25 countries; 30% were diagnosed with ST-segment elevation myocardial infarction, 31% with non-ST-segment myocardial infarction, 26% with unstable angina, and 12% with another cardiac/noncardiac final diagnosis. The median age was 65 (interquartile range 55-75) years; 24% were >75 years old, and 33% were women. In general, increases were observed over time across the spectrum of ACS (1) in the use in the first 24 hours and at discharge of aspirin, clopidogrel, β-blockers, and angiotensin-converting enzyme inhibitors/receptor blockers; (2) in the use at discharge of statins; (3) in the early use of glycoprotein IIb/IIIa inhibitors and low-molecular-weight heparin; and (4) in the use of cardiac catheterization and percutaneous coronary intervention. An increase in the use of primary percutaneous coronary intervention and a similar decrease in the use of fibrinolysis in ST-segment elevation myocardial infarction were also seen. Conclusions: Over the course of 7 years, general increases in the use of evidence-based therapies for ACS patients were observed in the expanded GRACE.
AB - Background: The Global Registry of Acute Coronary Events (GRACE)-a prospective, multinational study of patients hospitalized with acute coronary syndromes (ACSs)-was designed to improve the quality of care for patients with an ACS. Expanded GRACE aims to test the feasibility of a simplified data collection tool and provision of quarterly feedback to index individual hospital management practices to an international reference cohort. Methods: We describe the objectives; study design; study and data management; and the characteristics, management, and hospital outcomes of patients ≥18 years old enrolled with a presumptive diagnosis of ACS. Results: From 2001 to 2007, 31,982 patients were enrolled at 184 hospitals in 25 countries; 30% were diagnosed with ST-segment elevation myocardial infarction, 31% with non-ST-segment myocardial infarction, 26% with unstable angina, and 12% with another cardiac/noncardiac final diagnosis. The median age was 65 (interquartile range 55-75) years; 24% were >75 years old, and 33% were women. In general, increases were observed over time across the spectrum of ACS (1) in the use in the first 24 hours and at discharge of aspirin, clopidogrel, β-blockers, and angiotensin-converting enzyme inhibitors/receptor blockers; (2) in the use at discharge of statins; (3) in the early use of glycoprotein IIb/IIIa inhibitors and low-molecular-weight heparin; and (4) in the use of cardiac catheterization and percutaneous coronary intervention. An increase in the use of primary percutaneous coronary intervention and a similar decrease in the use of fibrinolysis in ST-segment elevation myocardial infarction were also seen. Conclusions: Over the course of 7 years, general increases in the use of evidence-based therapies for ACS patients were observed in the expanded GRACE.
UR - https://www.scopus.com/pages/publications/67650599501
U2 - 10.1016/j.ahj.2009.06.003
DO - 10.1016/j.ahj.2009.06.003
M3 - Article
C2 - 19619694
AN - SCOPUS:67650599501
SN - 0002-8703
VL - 158
SP - 201.e5
JO - American Heart Journal
JF - American Heart Journal
IS - 2
ER -