Towards extracellular vesicle-friendly microfluidic devices

Arturs Abols; Miks Priedols; Fēlikss Rūmnieks; Sintija Erentraute; Gunita Paidere; Karlis Grindulis; Gatis Mozoļevskis; Roberts Rimša

Towards extracellular vesicle-friendly microfluidic devices

Arturs Abols
, Miks Priedols
, Fēlikss Rūmnieks
, Sintija Erentraute
, Gunita Paidere
, Karlis Grindulis
, Gatis Mozoļevskis
, Roberts Rimša^*

^*Corresponding author for this work

Latvian Biomedical Research and Study Centre
University of Latvia

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Research › peer-review

Abstract

Extracellular vesicles (EV) have a potential to serve as novel disease biomarkers, however, currently EV isolation is complicated and with a high variability. Microfluidic devices utilizing multiple phenomena can be of use, however, polydimethylsiloxane (PDMS) is known to absorb and interact with lipophilic molecules. We have characterized alternative microfluidic device materials from EV manipulation perspective and conclude that offstoichiometry thio-lene (OSTE) material class is a better alternative material for EV handling in microfluidic channels thanks to lower interaction with lipophilic molecules and the material stability in lysis solutions.

Original language	English
Title of host publication	MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Pages	1417-1418
Publication status	Published - 2021

Publication series

Name	MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Keywords

OSTE
SEBS
separation
Extracellular vesicles
microfluidics
PDMS

OECD Field of Science

1.3 Physical Sciences

Cite this

Abols, A., Priedols, M., Rūmnieks, F., Erentraute, S., Paidere, G., Grindulis, K., Mozoļevskis, G., & Rimša, R. (2021). Towards extracellular vesicle-friendly microfluidic devices. In MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1417-1418). (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

@inproceedings{eeeba5d520524e8ab43e258d08de03aa,

title = "Towards extracellular vesicle-friendly microfluidic devices",

abstract = "Extracellular vesicles (EV) have a potential to serve as novel disease biomarkers, however, currently EV isolation is complicated and with a high variability. Microfluidic devices utilizing multiple phenomena can be of use, however, polydimethylsiloxane (PDMS) is known to absorb and interact with lipophilic molecules. We have characterized alternative microfluidic device materials from EV manipulation perspective and conclude that offstoichiometry thio-lene (OSTE) material class is a better alternative material for EV handling in microfluidic channels thanks to lower interaction with lipophilic molecules and the material stability in lysis solutions.",

keywords = "OSTE, SEBS, separation, Extracellular vesicles, microfluidics, PDMS",

author = "Arturs Abols and Miks Priedols and Fēlikss Rūmnieks and Sintija Erentraute and Gunita Paidere and Karlis Grindulis and Gatis Mozoļevskis and Roberts Rim{\v s}a",

year = "2021",

language = "English",

isbn = "9781733419031",

series = "MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

pages = "1417--1418",

booktitle = "MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

}

Abols, A, Priedols, M, Rūmnieks, F, Erentraute, S, Paidere, G, Grindulis, K, Mozoļevskis, G & Rimša, R 2021, Towards extracellular vesicle-friendly microfluidic devices. in MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, pp. 1417-1418.

Towards extracellular vesicle-friendly microfluidic devices. / Abols, Arturs; Priedols, Miks; Rūmnieks, Fēlikss et al.
MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2021. p. 1417-1418 (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Research › peer-review

TY - GEN

T1 - Towards extracellular vesicle-friendly microfluidic devices

AU - Abols, Arturs

AU - Priedols, Miks

AU - Rūmnieks, Fēlikss

AU - Erentraute, Sintija

AU - Paidere, Gunita

AU - Grindulis, Karlis

AU - Mozoļevskis, Gatis

AU - Rimša, Roberts

PY - 2021

Y1 - 2021

N2 - Extracellular vesicles (EV) have a potential to serve as novel disease biomarkers, however, currently EV isolation is complicated and with a high variability. Microfluidic devices utilizing multiple phenomena can be of use, however, polydimethylsiloxane (PDMS) is known to absorb and interact with lipophilic molecules. We have characterized alternative microfluidic device materials from EV manipulation perspective and conclude that offstoichiometry thio-lene (OSTE) material class is a better alternative material for EV handling in microfluidic channels thanks to lower interaction with lipophilic molecules and the material stability in lysis solutions.

AB - Extracellular vesicles (EV) have a potential to serve as novel disease biomarkers, however, currently EV isolation is complicated and with a high variability. Microfluidic devices utilizing multiple phenomena can be of use, however, polydimethylsiloxane (PDMS) is known to absorb and interact with lipophilic molecules. We have characterized alternative microfluidic device materials from EV manipulation perspective and conclude that offstoichiometry thio-lene (OSTE) material class is a better alternative material for EV handling in microfluidic channels thanks to lower interaction with lipophilic molecules and the material stability in lysis solutions.

KW - OSTE

KW - SEBS

KW - separation

KW - Extracellular vesicles

KW - microfluidics

KW - PDMS

UR - https://www.scopus.com/pages/publications/85136972575

M3 - Conference paper

SN - 9781733419031

T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

SP - 1417

EP - 1418

BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

ER -

Towards extracellular vesicle-friendly microfluidic devices

Abstract

Publication series

Keywords

OECD Field of Science

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