Abstract
We present the results of the interaction of iron oxide nanoparticles with some biologically active surfactants, namely, oleic acid and cytotoxic alkanolamine derivatives. Physico-chemical properties, as magnetization, magnetite concentration and particle diameter, of the prepared magnetic samples were studied. The nanoparticle size of 11 nm for toluene magnetic fluid determined by TEM is in good agreement with the data obtained by the method of magnetogranulometry. In vitro cytotoxic effect of water-soluble nanoparticles with different iron oxide:oleic acid molar ratio were revealed against human fibrosarcoma and mouse hepatoma cells. In vivo results using a sarcoma mouse model showed observable antitumor action.
| Original language | English |
|---|---|
| Pages (from-to) | 1428-1432 |
| Number of pages | 5 |
| Journal | Journal of Magnetism and Magnetic Materials |
| Volume | 321 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - May 2009 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Antitumor activity
- Cytotoxicity
- Iron oxide
- Magnetic nanoparticle
- Oleic acid
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