Data platform (genotyping data set) related to ERDF postdoctoral project No. 1.1.1.2/VIAA/4/20/718 "The role of vitamin D gene polymorphisms and its receptors in the modulation of intestinal inflammation in patients with relapsing and progressive forms of multiple sclerosis".

Data platform (genotyping dataset) related to the ERDF postdoctoral project No. 1.1.1.2/VIAA/4/20/718 “The role of vitamin D and its receptor gene polymorphisms in the modulation of intestinal inflammation in patients with relapsing and progressive forms of multiple sclerosis”. About the project and gathered data: The dataset contains genotyping data on 289 sex-balanced samples (approximately 60% women / 40% men)) were created at the the multiple sclerosis (MS) Clinic of the Latvian Maritime Medical Center (LMMC) in 2011 (disease duration of 1-51 years); the collection was updated within the framework of the ERDF MS project (2017-2020) and replenished during the ERDF postdoctoral project No. 1.1.1.2/VIAA/4/20/718 “The role of vitamin D and its receptor gene polymorphisms in the modulation of intestinal inflammation in patients with relapsing and progressive forms of multiple sclerosis” (2021-2023). For the Genotyping dataset relevant information for each patient from the MS disease cohort, referring to proteasomal gene genetic variations (microsatellites and SNPs): (HSMS006 (PSMA6), HSMS602 (FAM177A1), HSMS701 (KIAA0391), HSMS702 (KIAA0391) HSMS801 (KIAA0391), rs11543947(PSMB5), rs2277460 (mi110), rs1048990 (mi8) (PSMA6), rs1048990 (mi8) (PSMA6), rs2295826/rs2295827(PSMC6), rs2348071 (PSMA3), rs2071543, rs9357155 (PSMB8), rs17587(PSMB9), rs74421874 (PSMD9); rs9275596 from HLA region; vitamin D-related genes (VDR and GC) polymorphisms: rs2228570, rs1544410, rs7975232, rs731236 (VDR) and rs7041, rs4588 (GC). The study was funded from the Postdoc project No. 1.1.1.2/VIAA/4/20/718 "The role of vitamin D and its receptor gene polymorphisms in the modulation of intestinal inflammation in patients with relapsing and progressive forms of multiple sclerosis" . {"references": ["N. Paramonova, J. Kalnina et al., Genetic variations in the PSMA6 and PSMC6 proteasome genes are associated with multiple sclerosis risk and response to interferon beta therapy in Latvians. (2020), Int J Mol Med. doi: 10.3892/etm.2021.9909.", "N. Paramonova, I.Trapina, et al., An Intergenic rs9275596 Polymorphism on Chr. 6p21 Is Associated with Multiple Sclerosis in Latvians. (2020), Medicina DOI:10.3390/medicina56040154."]}