A three dimensional model for the interaction of MSH with the melanocortin-1 receptor

Peteris Prusis; Per Anders Frändberg; Ruta Muceniece; Ivars Kalvinsh; Jarl E.S. Wikberg

doi:10.1006/bbrc.1995.1647

A three dimensional model for the interaction of MSH with the melanocortin-1 receptor

Peteris Prusis
, Per Anders Frändberg
, Ruta Muceniece
, Ivars Kalvinsh
, Jarl E.S. Wikberg^*

^*Šī darba korespondējošais autors

Uppsala University
Latvian Institute of Organic Synthesis
Wa Pharm

Zinātniskās darbības rezultāts: Devums žurnālam › Zinātniskais raksts (žurnālā) › koleģiāli recenzēts

56 Atsauces (Scopus)

Kopsavilkums

A model for the interaction of the melanocortin-1 (MC1) receptor with MSH peptide has been constructed. The model was built by homology modelling bacteriorhodopsin as template. A cyclic analogue of MSH could be docked into binding pocket located between transmembrane (TM) domains 2, 3 and 6 of the receptor. The most significant receptor to ligand interactions occur between D117 in peptide and D121 in TM3 with arginine in peptide. The model finds support from earlier mutagenesis data.

Oriģinālvaloda	Angļu
Lapas (no-līdz)	205-210
Lapu skaits	6
Žurnāls	Biochemical and Biophysical Research Communications
Sējums	210
Izdevuma numurs	1
DOIs	https://doi.org/10.1006/bbrc.1995.1647
Publikācijas statuss	Publicēts - 1995
Ārēji publicēts	Jā

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title = "A three dimensional model for the interaction of MSH with the melanocortin-1 receptor",

abstract = "A model for the interaction of the melanocortin-1 (MC1) receptor with MSH peptide has been constructed. The model was built by homology modelling bacteriorhodopsin as template. A cyclic analogue of MSH could be docked into binding pocket located between transmembrane (TM) domains 2, 3 and 6 of the receptor. The most significant receptor to ligand interactions occur between D117 in peptide and D121 in TM3 with arginine in peptide. The model finds support from earlier mutagenesis data.",

author = "Peteris Prusis and Fr{\"a}ndberg, \{Per Anders\} and Ruta Muceniece and Ivars Kalvinsh and Wikberg, \{Jarl E.S.\}",

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AU - Muceniece, Ruta

AU - Kalvinsh, Ivars

AU - Wikberg, Jarl E.S.

PY - 1995

Y1 - 1995

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AB - A model for the interaction of the melanocortin-1 (MC1) receptor with MSH peptide has been constructed. The model was built by homology modelling bacteriorhodopsin as template. A cyclic analogue of MSH could be docked into binding pocket located between transmembrane (TM) domains 2, 3 and 6 of the receptor. The most significant receptor to ligand interactions occur between D117 in peptide and D121 in TM3 with arginine in peptide. The model finds support from earlier mutagenesis data.

UR - https://www.scopus.com/pages/publications/0029008390

U2 - 10.1006/bbrc.1995.1647

DO - 10.1006/bbrc.1995.1647

M3 - Article

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A three dimensional model for the interaction of MSH with the melanocortin-1 receptor

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