Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence

Angela J. Frodsham; Lyna Zhang; Uga Dumpis; Nor Azizah Mohd Taib; Steve Best; Andrew Durham; Branwen J.W. Hennig; Simon Hellier; Susanne Knapp; Mark Wright; Maria Chiaramonte; John I. Bell; Mary Graves; Hilton C. Whittle; Howard C. Thomas; Mark R. Thursz; Adrian V.S. Hill

doi:10.1073/pnas.0602800103

Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence

Angela J. Frodsham
, Lyna Zhang
, Uga Dumpis
, Nor Azizah Mohd Taib
, Steve Best
, Andrew Durham
, Branwen J.W. Hennig
, Simon Hellier
, Susanne Knapp
, Mark Wright
, Maria Chiaramonte
, John I. Bell
, Mary Graves
, Hilton C. Whittle
, Howard C. Thomas
, Mark R. Thursz^*
, Adrian V.S. Hill

^*Šī darba korespondējošais autors

Pētījuma izpildes rezultāts: Devums žurnālam › Zinātniskais raksts (žurnālā) › koleģiāli recenzēts

101 Atsauces (Scopus)

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Persistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95% of those infected at birth and 15% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in ≈350 million persistent carriers worldwide. Via a whole genome scan in Gambian families, we have identified a major susceptibility locus as a cluster of class II cytokine receptor genes on chromosome 21q22. Coding changes in two of these genes, the type IIFN receptor gene, IFN-AR2, and the IL-10RB gene that encodes a receptor chain for IL-10-related cytokines including the IFN-As, are associated with viral clearance (haplotype P value = 0.0003), and in vitro assays support functional roles for these variants in receptor signaling.

Oriģinālvaloda	Angļu
Lapas (no-līdz)	9148-9153
Lapu skaits	6
Žurnāls	Proceedings of the National Academy of Sciences of the United States of America
Sējums	103
Izdevuma numurs	24
DOIs	https://doi.org/10.1073/pnas.0602800103
Publikācijas statuss	Publicēts - 13 jūn. 2006
Ārēji publicēts	Jā

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Frodsham, A. J., Zhang, L., Dumpis, U., Taib, N. A. M., Best, S., Durham, A., Hennig, B. J. W., Hellier, S., Knapp, S., Wright, M., Chiaramonte, M., Bell, J. I., Graves, M., Whittle, H. C., Thomas, H. C., Thursz, M. R., & Hill, A. V. S. (2006). Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. Proceedings of the National Academy of Sciences of the United States of America, 103(24), 9148-9153. https://doi.org/10.1073/pnas.0602800103

@article{cd933c37b66c43feba9d4400c16d352d,

title = "Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence",

abstract = "Persistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95\% of those infected at birth and 15\% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in ≈350 million persistent carriers worldwide. Via a whole genome scan in Gambian families, we have identified a major susceptibility locus as a cluster of class II cytokine receptor genes on chromosome 21q22. Coding changes in two of these genes, the type IIFN receptor gene, IFN-AR2, and the IL-10RB gene that encodes a receptor chain for IL-10-related cytokines including the IFN-As, are associated with viral clearance (haplotype P value = 0.0003), and in vitro assays support functional roles for these variants in receptor signaling.",

keywords = "Complex trait, IL-10, Interferon, Susceptibility, Virus",

author = "Frodsham, \{Angela J.\} and Lyna Zhang and Uga Dumpis and Taib, \{Nor Azizah Mohd\} and Steve Best and Andrew Durham and Hennig, \{Branwen J.W.\} and Simon Hellier and Susanne Knapp and Mark Wright and Maria Chiaramonte and Bell, \{John I.\} and Mary Graves and Whittle, \{Hilton C.\} and Thomas, \{Howard C.\} and Thursz, \{Mark R.\} and Hill, \{Adrian V.S.\}",

year = "2006",

month = jun,

day = "13",

doi = "10.1073/pnas.0602800103",

language = "English",

volume = "103",

pages = "9148--9153",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "24",

}

Frodsham, AJ, Zhang, L, Dumpis, U, Taib, NAM, Best, S, Durham, A, Hennig, BJW, Hellier, S, Knapp, S, Wright, M, Chiaramonte, M, Bell, JI, Graves, M, Whittle, HC, Thomas, HC, Thursz, MR & Hill, AVS 2006, 'Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence', Proceedings of the National Academy of Sciences of the United States of America, sēj. 103, Nr. 24, lpp. 9148-9153. https://doi.org/10.1073/pnas.0602800103

Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. / Frodsham, Angela J.; Zhang, Lyna; Dumpis, Uga u.c.
(gadā): Proceedings of the National Academy of Sciences of the United States of America, Sēj. 103, Nr. 24, 13.06.2006, lpp. 9148-9153.

Pētījuma izpildes rezultāts: Devums žurnālam › Zinātniskais raksts (žurnālā) › koleģiāli recenzēts

TY - JOUR

T1 - Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence

AU - Frodsham, Angela J.

AU - Zhang, Lyna

AU - Dumpis, Uga

AU - Taib, Nor Azizah Mohd

AU - Best, Steve

AU - Durham, Andrew

AU - Hennig, Branwen J.W.

AU - Hellier, Simon

AU - Knapp, Susanne

AU - Wright, Mark

AU - Chiaramonte, Maria

AU - Bell, John I.

AU - Graves, Mary

AU - Whittle, Hilton C.

AU - Thomas, Howard C.

AU - Thursz, Mark R.

AU - Hill, Adrian V.S.

PY - 2006/6/13

Y1 - 2006/6/13

N2 - Persistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95% of those infected at birth and 15% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in ≈350 million persistent carriers worldwide. Via a whole genome scan in Gambian families, we have identified a major susceptibility locus as a cluster of class II cytokine receptor genes on chromosome 21q22. Coding changes in two of these genes, the type IIFN receptor gene, IFN-AR2, and the IL-10RB gene that encodes a receptor chain for IL-10-related cytokines including the IFN-As, are associated with viral clearance (haplotype P value = 0.0003), and in vitro assays support functional roles for these variants in receptor signaling.

AB - Persistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95% of those infected at birth and 15% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in ≈350 million persistent carriers worldwide. Via a whole genome scan in Gambian families, we have identified a major susceptibility locus as a cluster of class II cytokine receptor genes on chromosome 21q22. Coding changes in two of these genes, the type IIFN receptor gene, IFN-AR2, and the IL-10RB gene that encodes a receptor chain for IL-10-related cytokines including the IFN-As, are associated with viral clearance (haplotype P value = 0.0003), and in vitro assays support functional roles for these variants in receptor signaling.

KW - Complex trait

KW - IL-10

KW - Interferon

KW - Susceptibility

KW - Virus

UR - https://www.scopus.com/pages/publications/33745134040

U2 - 10.1073/pnas.0602800103

DO - 10.1073/pnas.0602800103

M3 - Article

C2 - 16757563

AN - SCOPUS:33745134040

SN - 0027-8424

VL - 103

SP - 9148

EP - 9153

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 24

ER -

Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence

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