TY - JOUR
T1 - Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain
AU - Rieckmann, Nina
AU - Neumann, Konrad
AU - Feger, Sarah
AU - Ibes, Paolo
AU - Napp, Adriane
AU - Preuß, Daniel
AU - Dreger, Henryk
AU - Feuchtner, Gudrun
AU - Plank, Fabian
AU - Suchánek, Vojtěch
AU - Veselka, Josef
AU - Engstrøm, Thomas
AU - Kofoed, Klaus F.
AU - Schröder, Stephen
AU - Zelesny, Thomas
AU - Gutberlet, Matthias
AU - Woinke, Michael
AU - Maurovich-Horvat, Pál
AU - Merkely, Béla
AU - Donnelly, Patrick
AU - Ball, Peter
AU - Dodd, Jonathan D.
AU - Hensey, Mark
AU - Loi, Bruno
AU - Saba, Luca
AU - Francone, Marco
AU - Mancone, Massimo
AU - Berzina, Marina
AU - Erglis, Andrejs
AU - Vaitiekiene, Audrone
AU - Zajanckauskiene, Laura
AU - Harań, Tomasz
AU - Suckiel, Malgorzata Ilnicka
AU - Faria, Rita
AU - Gama-Ribeiro, Vasco
AU - Benedek, Imre
AU - Rodean, Ioana
AU - Adjić, Filip
AU - Čemerlić Adjić, Nada
AU - Rodriguez-Palomares, José
AU - Garcia Del Blanco, Bruno
AU - Brooksbank, Katriona
AU - Collison, Damien
AU - Davis, Gershan
AU - Thwaite, Erica
AU - Knuuti, Juhani
AU - Saraste, Antti
AU - Kȩpka, Cezary
AU - Kruk, Mariusz
AU - Benedek, Theodora
AU - Ratiu, Mihaela
AU - Neskovic, Aleksandar N.
AU - Vidakovic, Radosav
AU - Diez, Ignacio
AU - Lecumberri, Iñigo
AU - Fisher, Michael
AU - Ruzsics, Balasz
AU - Hollingworth, William
AU - Gutiérrez-Ibarluzea, Iñaki
AU - Dewey, Marc
AU - Müller-Nordhorn, Jacqueline
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/5/14
Y1 - 2020/5/14
N2 - Background: Health-related quality of life (HRQoL) is impaired in patients with stable angina but patients often present with other forms of chest pain. The aim of this study was to compare the pre-diagnostic HRQoL in patients with suspected coronary artery disease (CAD) according to angina type, gender, and presence of obstructive CAD. Methods: From the pilot study for the European DISCHARGE trial, we analysed data from 24 sites including 1263 patients (45.9% women, 61.1 ± 11.3 years) who were clinically referred for invasive coronary angiography (ICA; 617 patients) or coronary computed tomography angiography (CTA; 646 patients). Prior to the procedures, patients completed HRQoL questionnaires: the Short Form (SF)-12v2, the EuroQoL (EQ-5D-3 L) and the Hospital Anxiety and Depression Scale. Results: Fifty-five percent of ICA and 35% of CTA patients had typical angina, 23 and 33% had atypical angina, 18 and 28% had non-anginal chest discomfort and 5 and 5% had other chest discomfort, respectively. Patients with typical angina had the poorest physical functioning compared to the other angina groups (SF-12 physical component score; 41.2 ± 8.8, 43.3 ± 9.1, 46.2 ± 9.0, 46.4 ± 11.4, respectively, all age and gender-adjusted p < 0.01), and highest anxiety levels (8.3 ± 4.1, 7.5 ± 4.1, 6.5 ± 4.0, 4.7 ± 4.5, respectively, all adjusted p < 0.01). On all other measures, patients with typical or atypical angina had lower HRQoL compared to the two other groups (all adjusted p < 0.05). HRQoL did not differ between patients with and without obstructive CAD while women had worse HRQoL compared with men, irrespective of age and angina type. Conclusions: Prior to a diagnostic procedure for stable chest pain, HRQoL is associated with chest pain characteristics, but not with obstructive CAD, and is significantly lower in women. Trial registration: Clinicaltrials.gov, NCT02400229.
AB - Background: Health-related quality of life (HRQoL) is impaired in patients with stable angina but patients often present with other forms of chest pain. The aim of this study was to compare the pre-diagnostic HRQoL in patients with suspected coronary artery disease (CAD) according to angina type, gender, and presence of obstructive CAD. Methods: From the pilot study for the European DISCHARGE trial, we analysed data from 24 sites including 1263 patients (45.9% women, 61.1 ± 11.3 years) who were clinically referred for invasive coronary angiography (ICA; 617 patients) or coronary computed tomography angiography (CTA; 646 patients). Prior to the procedures, patients completed HRQoL questionnaires: the Short Form (SF)-12v2, the EuroQoL (EQ-5D-3 L) and the Hospital Anxiety and Depression Scale. Results: Fifty-five percent of ICA and 35% of CTA patients had typical angina, 23 and 33% had atypical angina, 18 and 28% had non-anginal chest discomfort and 5 and 5% had other chest discomfort, respectively. Patients with typical angina had the poorest physical functioning compared to the other angina groups (SF-12 physical component score; 41.2 ± 8.8, 43.3 ± 9.1, 46.2 ± 9.0, 46.4 ± 11.4, respectively, all age and gender-adjusted p < 0.01), and highest anxiety levels (8.3 ± 4.1, 7.5 ± 4.1, 6.5 ± 4.0, 4.7 ± 4.5, respectively, all adjusted p < 0.01). On all other measures, patients with typical or atypical angina had lower HRQoL compared to the two other groups (all adjusted p < 0.05). HRQoL did not differ between patients with and without obstructive CAD while women had worse HRQoL compared with men, irrespective of age and angina type. Conclusions: Prior to a diagnostic procedure for stable chest pain, HRQoL is associated with chest pain characteristics, but not with obstructive CAD, and is significantly lower in women. Trial registration: Clinicaltrials.gov, NCT02400229.
KW - Angina
KW - Chest pain
KW - Computed tomography angiography
KW - Coronary artery disease
KW - Health-related quality of life
KW - Invasive coronary angiography
UR - https://www.scopus.com/pages/publications/85084796550
U2 - 10.1186/s12955-020-01312-4
DO - 10.1186/s12955-020-01312-4
M3 - Article
C2 - 32410687
AN - SCOPUS:85084796550
SN - 1477-7525
VL - 18
JO - Health and Quality of Life Outcomes
JF - Health and Quality of Life Outcomes
IS - 1
M1 - 140
ER -
3. IAM — Laba Veselība un Labbūtība