Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System

Aivars Cīrulis; Ivars Silamiķelis; Edgars Laķis; Kaspars Megnis; Angelika Voronova; Laura Ansone; Janis Pjalkovskis; Rolands Strazdiņš; Monta Brīvība; Jānis Kloviņš

doi:10.2478/prolas-2026-0007

Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System

Aivars Cīrulis^*
, Ivars Silamiķelis
, Edgars Laķis
, Kaspars Megnis
, Angelika Voronova
, Laura Ansone
, Janis Pjalkovskis
, Rolands Strazdiņš
, Monta Brīvība
, Jānis Kloviņš

^*Šī darba korespondējošais autors

Latvijas Biomedicīnas pētījumu un studiju centrs
Latvian Biomedical Research and Study Centre
Latvian Institute of Organic Synthesis

Zinātniskās darbības rezultāts: Devums žurnālam › Konferences tēzes (žurnālā) › koleģiāli recenzēts

10 Lejupielādes (Pure)

Kopsavilkums

Baltic populations are often underrepresented in genomic resources, hindering the interpretation of variants, the calculation of polygenic risk scores (PRSs), and disease estimates. The development of a population-scale reference dataset of Latvian genetic variation may bridge the gap in European genomes by improving imputation and variant interpretation. These benefits are maximised when the dataset is integrated into broader frameworks, such as the Genome of Europe (GoE).

Oriģinālvaloda	Angļu
Lapas (no-līdz)	49-49
Žurnāls	Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Sējums	80
Izdevuma numurs	1/2
DOIs	https://doi.org/10.2478/prolas-2026-0007
Publikācijas statuss	Publicēts - maijs 2026

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Cīrulis, A., Silamiķelis, I., Laķis, E., Megnis, K., Voronova, A., Ansone, L., Pjalkovskis, J., Strazdiņš, R., Brīvība, M., & Kloviņš, J. (2026). Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 80(1/2), 49-49. https://doi.org/10.2478/prolas-2026-0007

Cīrulis, Aivars ; Silamiķelis, Ivars ; Laķis, Edgars u.c. / Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System. (gadā): Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences. 2026 ; Sēj. 80, Nr. 1/2. lpp. 49-49.

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title = "Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System",

abstract = "Baltic populations are often underrepresented in genomic resources, hindering the interpretation of variants, the calculation of polygenic risk scores (PRSs), and disease estimates. The development of a population-scale reference dataset of Latvian genetic variation may bridge the gap in European genomes by improving imputation and variant interpretation. These benefits are maximised when the dataset is integrated into broader frameworks, such as the Genome of Europe (GoE).",

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year = "2026",

month = may,

doi = "10.2478/prolas-2026-0007",

language = "English",

volume = "80",

pages = "49--49",

journal = "Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences",

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Cīrulis, A, Silamiķelis, I, Laķis, E, Megnis, K, Voronova, A, Ansone, L, Pjalkovskis, J, Strazdiņš, R, Brīvība, M & Kloviņš, J 2026, 'Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, sēj. 80, Nr. 1/2, lpp. 49-49. https://doi.org/10.2478/prolas-2026-0007

Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System. / Cīrulis, Aivars; Silamiķelis, Ivars; Laķis, Edgars u.c.
(gadā): Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, Sēj. 80, Nr. 1/2, 05.2026, lpp. 49-49.

Zinātniskās darbības rezultāts: Devums žurnālam › Konferences tēzes (žurnālā) › koleģiāli recenzēts

TY - JOUR

T1 - Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System

AU - Cīrulis, Aivars

AU - Silamiķelis, Ivars

AU - Laķis, Edgars

AU - Megnis, Kaspars

AU - Voronova, Angelika

AU - Ansone, Laura

AU - Pjalkovskis, Janis

AU - Strazdiņš, Rolands

AU - Brīvība, Monta

AU - Kloviņš, Jānis

PY - 2026/5

Y1 - 2026/5

N2 - Baltic populations are often underrepresented in genomic resources, hindering the interpretation of variants, the calculation of polygenic risk scores (PRSs), and disease estimates. The development of a population-scale reference dataset of Latvian genetic variation may bridge the gap in European genomes by improving imputation and variant interpretation. These benefits are maximised when the dataset is integrated into broader frameworks, such as the Genome of Europe (GoE).

AB - Baltic populations are often underrepresented in genomic resources, hindering the interpretation of variants, the calculation of polygenic risk scores (PRSs), and disease estimates. The development of a population-scale reference dataset of Latvian genetic variation may bridge the gap in European genomes by improving imputation and variant interpretation. These benefits are maximised when the dataset is integrated into broader frameworks, such as the Genome of Europe (GoE).

KW - Genome reference

KW - Genomic database

KW - Latvia

U2 - 10.2478/prolas-2026-0007

DO - 10.2478/prolas-2026-0007

M3 - Meeting abstract

SN - 1407-009X

VL - 80

SP - 49

EP - 49

JO - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

JF - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

IS - 1/2

ER -

Cīrulis A, Silamiķelis I, Laķis E, Megnis K, Voronova A, Ansone L u.c. Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences. 2026 maijs;80(1/2):49-49. doi: 10.2478/prolas-2026-0007

Latvian Genome Reference Project in the Genome of Europe: Genomic Data Infrastructure-enabled Interoperability with the National Genomic Database Information System

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OECD Zinātnes nozare

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