Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite

Andris Antuzevičs; Arita Dubņika; A Antuzevics; A. Dubnika; A Dubnika; T Goto; A Kizalaite; T. Murauskas; A. Kizalaite; A Zarkov; T Murauskas; O Jr Stewart; T Goto; T Murauskas; T. Goto; O. Stewart; S.L. Stoll; A Antuzevics; T. Sekino; A Antuzevics; A. Zarkov; A Kizalaite; A Kizalaite; T Goto; A Kizalaite; A Zarkov; T Murauskas; A Dubnika; A Antuzevics; A Zarkov; T Murauskas; T Goto; A Zarkov; A Dubnika

doi:10.1016/j.ceramint.2024.05.157

Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite

Andris Antuzevičs
, Arita Dubņika
, A Antuzevics
, A. Dubnika
, A Dubnika
, T Goto
, A Kizalaite
, T. Murauskas
, A. Kizalaite
, A Zarkov
, T Murauskas
, O Jr Stewart
, T Goto
, T Murauskas
, T. Goto
, O. Stewart
, S.L. Stoll
, A Antuzevics
, T. Sekino
, A Antuzevics

A. Zarkov, A Kizalaite, A Kizalaite, T Goto, A Kizalaite, A Zarkov, T Murauskas, A Dubnika, A Antuzevics, A Zarkov, T Murauskas, T Goto, A Zarkov, A Dubnika

LU Cietvielu fizikas institūts

Rīgas Tehniskā universitāte
Vilniaus Universitetas
Osaka University
Georgetown University

Zinātniskās darbības rezultāts: Devums žurnālam › Zinātniskais raksts (žurnālā) › koleģiāli recenzēts

3 Atsauces (Scopus)

Kopsavilkums

In this work, manganese whitlockite (Mn-WH, Ca₁₈Mn₂(HPO₄)₂(PO₄)₁₂) was successfully synthesized and comprehensively characterized. This material is a manganese-containing analog of the biomineral magnesium whitlockite (Mg-WH, Ca₁₈Mg₂(HPO₄)₂(PO₄)₁₂). The synthesis was performed via a low-temperature dissolution-precipitation process in aqueous medium under ambient pressure at 75 °C using dicalcium phosphate dehydrate and manganese acetate tetrahydrate as starting materials. The crystal structure of the synthesized powder was determined by powder X-ray diffraction, FTIR and Raman spectroscopies, demonstrating the presence of characteristic structural units. Morphological features and elemental distribution within the synthesized powder were studied by SEM/EDX analysis. XPS, EPR and magnetic studies confirmed the presence of Mn ions in a divalent state. Temperature-dependent magnetic measurements revealed a paramagnetic behavior of Mn-WH down to 5 K. In vitro cytotoxicity experiments were performed with MC3T3-E1 preosteoblastic cell line.

Oriģinālvaloda	Angļu
Lapas (no-līdz)	28490-28497
Lapu skaits	8
Žurnāls	Ceramics International
Sējums	50
Izdevuma numurs	16
DOIs	https://doi.org/10.1016/j.ceramint.2024.05.157
Publikācijas statuss	Publicēts - 15 aug. 2024

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Antuzevičs, A., Dubņika, A., Antuzevics, A., Dubnika, A., Dubnika, A., Goto, T., Kizalaite, A., Murauskas, T., Kizalaite, A., Zarkov, A., Murauskas, T., Stewart, O. J., Goto, T., Murauskas, T., Goto, T., Stewart, O., Stoll, S. L., Antuzevics, A., Sekino, T., ... Dubnika, A. (2024). Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite. Ceramics International, 50(16), 28490-28497. https://doi.org/10.1016/j.ceramint.2024.05.157

@article{456cefcbe9924407b3214fdc003f7424,

title = "Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite",

abstract = "In this work, manganese whitlockite (Mn-WH, Ca18Mn2(HPO4)2(PO4)12) was successfully synthesized and comprehensively characterized. This material is a manganese-containing analog of the biomineral magnesium whitlockite (Mg-WH, Ca18Mg2(HPO4)2(PO4)12). The synthesis was performed via a low-temperature dissolution-precipitation process in aqueous medium under ambient pressure at 75 °C using dicalcium phosphate dehydrate and manganese acetate tetrahydrate as starting materials. The crystal structure of the synthesized powder was determined by powder X-ray diffraction, FTIR and Raman spectroscopies, demonstrating the presence of characteristic structural units. Morphological features and elemental distribution within the synthesized powder were studied by SEM/EDX analysis. XPS, EPR and magnetic studies confirmed the presence of Mn ions in a divalent state. Temperature-dependent magnetic measurements revealed a paramagnetic behavior of Mn-WH down to 5 K. In vitro cytotoxicity experiments were performed with MC3T3-E1 preosteoblastic cell line.",

keywords = "Ca Mn (HPO ) (PO ), Cell viability, Dissolution-precipitation, Manganese whitlockite",

author = "Andris Antuzevi{\v c}s and Arita Dubņika and A Antuzevics and A. Dubnika and A Dubnika and T Goto and A Kizalaite and T. Murauskas and A. Kizalaite and A Zarkov and T Murauskas and Stewart, \{O Jr\} and T Goto and T Murauskas and T. Goto and O. Stewart and S.L. Stoll and A Antuzevics and T. Sekino and A Antuzevics and A. Zarkov and A Kizalaite and A Kizalaite and T Goto and A Kizalaite and A Zarkov and T Murauskas and A Dubnika and A Antuzevics and A Zarkov and T Murauskas and T Goto and A Zarkov and A Dubnika",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd and Techna Group S.r.l.",

year = "2024",

month = aug,

day = "15",

doi = "10.1016/j.ceramint.2024.05.157",

language = "English",

volume = "50",

pages = "28490--28497",

journal = "Ceramics International",

issn = "0272-8842",

publisher = "Elsevier Ltd",

number = "16",

}

Antuzevičs, A, Dubņika, A, Antuzevics, A, Dubnika, A, Dubnika, A, Goto, T, Kizalaite, A, Murauskas, T, Kizalaite, A, Zarkov, A, Murauskas, T, Stewart, OJ, Goto, T, Murauskas, T, Goto, T, Stewart, O, Stoll, SL, Antuzevics, A, Sekino, T, Antuzevics, A, Zarkov, A, Kizalaite, A, Kizalaite, A, Goto, T, Kizalaite, A, Zarkov, A, Murauskas, T, Dubnika, A, Antuzevics, A, Zarkov, A, Murauskas, T, Goto, T, Zarkov, A & Dubnika, A 2024, 'Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite', Ceramics International, sēj. 50, Nr. 16, lpp. 28490-28497. https://doi.org/10.1016/j.ceramint.2024.05.157

TY - JOUR

T1 - Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite

AU - Antuzevičs, Andris

AU - Dubņika, Arita

AU - Antuzevics, A

AU - Dubnika, A.

AU - Dubnika, A

AU - Goto, T

AU - Kizalaite, A

AU - Murauskas, T.

AU - Kizalaite, A.

AU - Zarkov, A

AU - Murauskas, T

AU - Stewart, O Jr

AU - Goto, T

AU - Murauskas, T

AU - Goto, T.

AU - Stewart, O.

AU - Stoll, S.L.

AU - Antuzevics, A

AU - Sekino, T.

AU - Antuzevics, A

AU - Zarkov, A.

AU - Kizalaite, A

AU - Goto, T

AU - Kizalaite, A

AU - Zarkov, A

AU - Murauskas, T

AU - Dubnika, A

AU - Antuzevics, A

AU - Zarkov, A

AU - Murauskas, T

AU - Goto, T

AU - Zarkov, A

AU - Dubnika, A

PY - 2024/8/15

Y1 - 2024/8/15

N2 - In this work, manganese whitlockite (Mn-WH, Ca18Mn2(HPO4)2(PO4)12) was successfully synthesized and comprehensively characterized. This material is a manganese-containing analog of the biomineral magnesium whitlockite (Mg-WH, Ca18Mg2(HPO4)2(PO4)12). The synthesis was performed via a low-temperature dissolution-precipitation process in aqueous medium under ambient pressure at 75 °C using dicalcium phosphate dehydrate and manganese acetate tetrahydrate as starting materials. The crystal structure of the synthesized powder was determined by powder X-ray diffraction, FTIR and Raman spectroscopies, demonstrating the presence of characteristic structural units. Morphological features and elemental distribution within the synthesized powder were studied by SEM/EDX analysis. XPS, EPR and magnetic studies confirmed the presence of Mn ions in a divalent state. Temperature-dependent magnetic measurements revealed a paramagnetic behavior of Mn-WH down to 5 K. In vitro cytotoxicity experiments were performed with MC3T3-E1 preosteoblastic cell line.

AB - In this work, manganese whitlockite (Mn-WH, Ca18Mn2(HPO4)2(PO4)12) was successfully synthesized and comprehensively characterized. This material is a manganese-containing analog of the biomineral magnesium whitlockite (Mg-WH, Ca18Mg2(HPO4)2(PO4)12). The synthesis was performed via a low-temperature dissolution-precipitation process in aqueous medium under ambient pressure at 75 °C using dicalcium phosphate dehydrate and manganese acetate tetrahydrate as starting materials. The crystal structure of the synthesized powder was determined by powder X-ray diffraction, FTIR and Raman spectroscopies, demonstrating the presence of characteristic structural units. Morphological features and elemental distribution within the synthesized powder were studied by SEM/EDX analysis. XPS, EPR and magnetic studies confirmed the presence of Mn ions in a divalent state. Temperature-dependent magnetic measurements revealed a paramagnetic behavior of Mn-WH down to 5 K. In vitro cytotoxicity experiments were performed with MC3T3-E1 preosteoblastic cell line.

KW - Ca Mn (HPO ) (PO )

KW - Cell viability

KW - Dissolution-precipitation

KW - Manganese whitlockite

UR - https://www.scopus.com/pages/publications/85192827949

U2 - 10.1016/j.ceramint.2024.05.157

DO - 10.1016/j.ceramint.2024.05.157

M3 - Article

SN - 0272-8842

VL - 50

SP - 28490

EP - 28497

JO - Ceramics International

JF - Ceramics International

IS - 16

ER -

Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite

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