Microwave-promoted automated synthesis of a coumarin library

M. Katkevičs; A. Kontijevskis; I. Mutule; E. Sūna

doi:10.1007/s10593-007-0025-x

Microwave-promoted automated synthesis of a coumarin library

M. Katkevičs^*
, A. Kontijevskis
, I. Mutule
, E. Sūna

^*Šī darba korespondējošais autors

Latvian Institute of Organic Synthesis

Zinātniskās darbības rezultāts: Devums žurnālam › Zinātniskais raksts (žurnālā) › koleģiāli recenzēts

31 Atsauces (Scopus)

Kopsavilkums

A 30-membered library of coumarins has been synthesized in a microwave-assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction medium. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of a specially-built microwave synthesizer with liquid handling tools rendered the automated synthesis of a coumarin library feasible.

Oriģinālvaloda	Angļu
Lapas (no-līdz)	151-159
Lapu skaits	9
Žurnāls	Chemistry of Heterocyclic Compounds
Sējums	43
Izdevuma numurs	2
DOIs	https://doi.org/10.1007/s10593-007-0025-x
Publikācijas statuss	Publicēts - febr. 2007
Ārēji publicēts	Jā

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abstract = "A 30-membered library of coumarins has been synthesized in a microwave-assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction medium. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of a specially-built microwave synthesizer with liquid handling tools rendered the automated synthesis of a coumarin library feasible.",

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AU - Kontijevskis, A.

AU - Mutule, I.

AU - Sūna, E.

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N2 - A 30-membered library of coumarins has been synthesized in a microwave-assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction medium. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of a specially-built microwave synthesizer with liquid handling tools rendered the automated synthesis of a coumarin library feasible.

AB - A 30-membered library of coumarins has been synthesized in a microwave-assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction medium. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of a specially-built microwave synthesizer with liquid handling tools rendered the automated synthesis of a coumarin library feasible.

KW - Coumarin

KW - Library synthesis

KW - Microwave promoted synthesis

UR - https://www.scopus.com/pages/publications/34249024636

U2 - 10.1007/s10593-007-0025-x

DO - 10.1007/s10593-007-0025-x

M3 - Article

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ER -

Microwave-promoted automated synthesis of a coumarin library

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