Role of abca7 in human health and in alzheimer’s disease

Shiraz Dib; Jens Pahnke; Fabien Gosselet

doi:10.3390/ijms22094603

Role of abca7 in human health and in alzheimer’s disease

Shiraz Dib
, Jens Pahnke
, Fabien Gosselet^*

^*Šī darba korespondējošais autors

Neiromedicīnas un neirozinātņu nodaļa

Université d'Artois
Leibniz Institute of Plant Biochemistry
University of Lübeck
University of Oslo

Zinātniskās darbības rezultāts: Devums žurnālam › Pārskata raksts › koleģiāli recenzēts

70 Atsauces (Scopus)

Kopsavilkums

Several studies, including genome wide association studies (GWAS), have strongly sug-gested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic deter-minant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.

Oriģinālvaloda	Angļu
Raksta numurs	4603
Žurnāls	International Journal of Molecular Sciences
Sējums	22
Izdevuma numurs	9
DOIs	https://doi.org/10.3390/ijms22094603
Publikācijas statuss	Publicēts - 1 maijs 2021

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title = "Role of abca7 in human health and in alzheimer{\textquoteright}s disease",

abstract = "Several studies, including genome wide association studies (GWAS), have strongly sug-gested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer{\textquoteright}s disease (AD). This ABC transporter is now considered as an important genetic deter-minant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.",

keywords = "ABCA7, Alzheimer{\textquoteright}s disease, Aβ peptides, Cholesterol, Phagocytosis",

author = "Shiraz Dib and Jens Pahnke and Fabien Gosselet",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = may,

day = "1",

doi = "10.3390/ijms22094603",

language = "English",

volume = "22",

journal = "International Journal of Molecular Sciences",

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TY - JOUR

T1 - Role of abca7 in human health and in alzheimer’s disease

AU - Dib, Shiraz

AU - Pahnke, Jens

AU - Gosselet, Fabien

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Several studies, including genome wide association studies (GWAS), have strongly sug-gested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic deter-minant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.

AB - Several studies, including genome wide association studies (GWAS), have strongly sug-gested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic deter-minant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.

KW - ABCA7

KW - Alzheimer’s disease

KW - Aβ peptides

KW - Cholesterol

KW - Phagocytosis

UR - https://www.mdpi.com/1422-0067/22/9/4603

UR - https://www.scopus.com/pages/publications/85104721017

U2 - 10.3390/ijms22094603

DO - 10.3390/ijms22094603

M3 - Review article

C2 - 33925691

SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 9

M1 - 4603

ER -

Role of abca7 in human health and in alzheimer’s disease

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