Role of the ubiquitin-proteasome protein degradation pathway in carcinogenesis, tumor progression and susceptibility to tumor treatment

N. Sjakste; T. Sjakste; U. Vikmanis

Role of the ubiquitin-proteasome protein degradation pathway in carcinogenesis, tumor progression and susceptibility to tumor treatment

N. Sjakste^*
, T. Sjakste
, U. Vikmanis

^*Šī darba korespondējošais autors

Zinātniskās darbības rezultāts: Devums žurnālam › Pārskata raksts › koleģiāli recenzēts

2 Atsauces (Scopus)

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The review summarizes data on involvement of the proteasomes and other enzymes performing the ubiquitin-mediated proteolysis in carcinogenesis, tumor biology and mechanisms of action of antitumor drugs. Increased or decreased susceptibility of oncoproteins and tumor suppressors can give rise to tumorigenesis. Proteasome composition and proteasome activity is altered in neoplastic cells. Novel antitumor drugs can be developed from the proteasome inhibitors.

Oriģinālvaloda	Angļu
Lapas (no-līdz)	243-248
Lapu skaits	6
Žurnāls	Experimental Oncology
Sējums	24
Izdevuma numurs	4
Publikācijas statuss	Publicēts - dec. 2002

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@article{6f4f3449c8de4663accb9cf04cb38255,

title = "Role of the ubiquitin-proteasome protein degradation pathway in carcinogenesis, tumor progression and susceptibility to tumor treatment",

abstract = "The review summarizes data on involvement of the proteasomes and other enzymes performing the ubiquitin-mediated proteolysis in carcinogenesis, tumor biology and mechanisms of action of antitumor drugs. Increased or decreased susceptibility of oncoproteins and tumor suppressors can give rise to tumorigenesis. Proteasome composition and proteasome activity is altered in neoplastic cells. Novel antitumor drugs can be developed from the proteasome inhibitors.",

keywords = "Cancer, Proteasomes",

author = "N. Sjakste and T. Sjakste and U. Vikmanis",

year = "2002",

month = dec,

language = "English",

volume = "24",

pages = "243--248",

journal = "Experimental Oncology",

issn = "1812-9269",

publisher = "Morion LLC",

number = "4",

}

TY - JOUR

T1 - Role of the ubiquitin-proteasome protein degradation pathway in carcinogenesis, tumor progression and susceptibility to tumor treatment

AU - Sjakste, N.

AU - Sjakste, T.

AU - Vikmanis, U.

PY - 2002/12

Y1 - 2002/12

N2 - The review summarizes data on involvement of the proteasomes and other enzymes performing the ubiquitin-mediated proteolysis in carcinogenesis, tumor biology and mechanisms of action of antitumor drugs. Increased or decreased susceptibility of oncoproteins and tumor suppressors can give rise to tumorigenesis. Proteasome composition and proteasome activity is altered in neoplastic cells. Novel antitumor drugs can be developed from the proteasome inhibitors.

AB - The review summarizes data on involvement of the proteasomes and other enzymes performing the ubiquitin-mediated proteolysis in carcinogenesis, tumor biology and mechanisms of action of antitumor drugs. Increased or decreased susceptibility of oncoproteins and tumor suppressors can give rise to tumorigenesis. Proteasome composition and proteasome activity is altered in neoplastic cells. Novel antitumor drugs can be developed from the proteasome inhibitors.

KW - Cancer

KW - Proteasomes

UR - https://www.scopus.com/pages/publications/0036971557

M3 - Review article

AN - SCOPUS:0036971557

SN - 1812-9269

VL - 24

SP - 243

EP - 248

JO - Experimental Oncology

JF - Experimental Oncology

IS - 4

ER -

Role of the ubiquitin-proteasome protein degradation pathway in carcinogenesis, tumor progression and susceptibility to tumor treatment

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