Synthesis, physico-chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer

Izolda Segal; Alla Zablotskaya; Edmunds Lukevics; Mikhail Maiorov; Dmitry Zablotsky; Elmars Blums; Irina Shestakova; Ilona Domracheva

doi:10.1002/aoc.1354

Synthesis, physico-chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer

Izolda Segal^*
, Alla Zablotskaya
, Edmunds Lukevics
, Mikhail Maiorov
, Dmitry Zablotsky
, Elmars Blums
, Irina Shestakova
, Ilona Domracheva

^*Šī darba korespondējošais autors

Latvian Institute of Organic Synthesis

Zinātniskās darbības rezultāts: Devums žurnālam › Zinātniskais raksts (žurnālā) › koleģiāli recenzēts

16 Atsauces (Scopus)

Kopsavilkums

New original water-soluble magnetic nanoparticles based on natural components, magnetite-oleic acid-biologically active silyl modified alkanolamine, were synthesized. Physico-chemical characterization, i.e. magnetic properties, concentration of magnetite, size of iron oxide core, of the nanoparticles synthesized and the corresponding magnetic fluids obtained, was carried out. Magnetic fluids were screened for in vitro cytotoxicity concerning human fibrosarcoma (HT-1080), mouse hepatoma (MG-22A) monolayer tumour cell lines and normal mouse fibroblasts (NIH 3T3). They possess low or moderate cytotoxic effects, are non-toxic, exhibit high NO-induction ability and strongly change tumour cell morphology.

Oriģinālvaloda	Angļu
Lapas (no-līdz)	82-88
Lapu skaits	7
Žurnāls	Applied Organometallic Chemistry
Sējums	22
Izdevuma numurs	2
DOIs	https://doi.org/10.1002/aoc.1354
Publikācijas statuss	Publicēts - febr. 2008

ANO IAM

Šis izpildes rezultāts palīdz sasniegt šādus ANO ilgtspējīgas attīstības mērķus (IAM)

3. IAM — Laba Veselība un Labbūtība

Piekļuve Dokumentiem

10.1002/aoc.1354

Citi faili un saites

Saite uz publikāciju Scopus

Citēt šo

@article{8561bde795524b81b1f563d085ae41af,

title = "Synthesis, physico-chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer",

abstract = "New original water-soluble magnetic nanoparticles based on natural components, magnetite-oleic acid-biologically active silyl modified alkanolamine, were synthesized. Physico-chemical characterization, i.e. magnetic properties, concentration of magnetite, size of iron oxide core, of the nanoparticles synthesized and the corresponding magnetic fluids obtained, was carried out. Magnetic fluids were screened for in vitro cytotoxicity concerning human fibrosarcoma (HT-1080), mouse hepatoma (MG-22A) monolayer tumour cell lines and normal mouse fibroblasts (NIH 3T3). They possess low or moderate cytotoxic effects, are non-toxic, exhibit high NO-induction ability and strongly change tumour cell morphology.",

keywords = "Alkanolamines, Cytotoxicity, Drug research, Iron oxide, Magnetic fluids, Magnetosomes, Nanoparticles, Organosilicon compounds",

author = "Izolda Segal and Alla Zablotskaya and Edmunds Lukevics and Mikhail Maiorov and Dmitry Zablotsky and Elmars Blums and Irina Shestakova and Ilona Domracheva",

year = "2008",

month = feb,

doi = "10.1002/aoc.1354",

language = "English",

volume = "22",

pages = "82--88",

journal = "Applied Organometallic Chemistry",

issn = "0268-2605",

publisher = "John Wiley and Sons Ltd",

number = "2",

}

Synthesis, physico-chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer. / Segal, Izolda; Zablotskaya, Alla; Lukevics, Edmunds u.c.
(gadā): Applied Organometallic Chemistry, Sēj. 22, Nr. 2, 02.2008, lpp. 82-88.

Zinātniskās darbības rezultāts: Devums žurnālam › Zinātniskais raksts (žurnālā) › koleģiāli recenzēts

TY - JOUR

T1 - Synthesis, physico-chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer

AU - Segal, Izolda

AU - Zablotskaya, Alla

AU - Lukevics, Edmunds

AU - Maiorov, Mikhail

AU - Zablotsky, Dmitry

AU - Blums, Elmars

AU - Shestakova, Irina

AU - Domracheva, Ilona

PY - 2008/2

Y1 - 2008/2

N2 - New original water-soluble magnetic nanoparticles based on natural components, magnetite-oleic acid-biologically active silyl modified alkanolamine, were synthesized. Physico-chemical characterization, i.e. magnetic properties, concentration of magnetite, size of iron oxide core, of the nanoparticles synthesized and the corresponding magnetic fluids obtained, was carried out. Magnetic fluids were screened for in vitro cytotoxicity concerning human fibrosarcoma (HT-1080), mouse hepatoma (MG-22A) monolayer tumour cell lines and normal mouse fibroblasts (NIH 3T3). They possess low or moderate cytotoxic effects, are non-toxic, exhibit high NO-induction ability and strongly change tumour cell morphology.

AB - New original water-soluble magnetic nanoparticles based on natural components, magnetite-oleic acid-biologically active silyl modified alkanolamine, were synthesized. Physico-chemical characterization, i.e. magnetic properties, concentration of magnetite, size of iron oxide core, of the nanoparticles synthesized and the corresponding magnetic fluids obtained, was carried out. Magnetic fluids were screened for in vitro cytotoxicity concerning human fibrosarcoma (HT-1080), mouse hepatoma (MG-22A) monolayer tumour cell lines and normal mouse fibroblasts (NIH 3T3). They possess low or moderate cytotoxic effects, are non-toxic, exhibit high NO-induction ability and strongly change tumour cell morphology.

KW - Alkanolamines

KW - Cytotoxicity

KW - Drug research

KW - Iron oxide

KW - Magnetic fluids

KW - Magnetosomes

KW - Nanoparticles

KW - Organosilicon compounds

UR - https://www.scopus.com/pages/publications/40749134166

U2 - 10.1002/aoc.1354

DO - 10.1002/aoc.1354

M3 - Article

AN - SCOPUS:40749134166

SN - 0268-2605

VL - 22

SP - 82

EP - 88

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

IS - 2

ER -

Synthesis, physico-chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer

Kopsavilkums

ANO IAM

Piekļuve Dokumentiem

Citi faili un saites

Nospiedums

Citēt šo