Water-soluble magnetic nanoparticles with biologically active stabilizers

Alla Zablotskaya; Izolda Segal; Edmunds Lukevics; Mikhail Maiorov; Dmitry Zablotsky; Elmars Blums; Irina Shestakova; Ilona Domracheva

doi:10.1016/j.jmmm.2009.02.060

Water-soluble magnetic nanoparticles with biologically active stabilizers

Alla Zablotskaya^*
, Izolda Segal
, Edmunds Lukevics
, Mikhail Maiorov
, Dmitry Zablotsky
, Elmars Blums
, Irina Shestakova
, Ilona Domracheva

^*Šī darba korespondējošais autors

Latvijas Organiskās sintēzes institūts

Zinātniskās darbības rezultāts: Devums žurnālam › Zinātniskais raksts (žurnālā) › koleģiāli recenzēts

18 Atsauces (Scopus)

Kopsavilkums

We present the results of the interaction of iron oxide nanoparticles with some biologically active surfactants, namely, oleic acid and cytotoxic alkanolamine derivatives. Physico-chemical properties, as magnetization, magnetite concentration and particle diameter, of the prepared magnetic samples were studied. The nanoparticle size of 11 nm for toluene magnetic fluid determined by TEM is in good agreement with the data obtained by the method of magnetogranulometry. In vitro cytotoxic effect of water-soluble nanoparticles with different iron oxide:oleic acid molar ratio were revealed against human fibrosarcoma and mouse hepatoma cells. In vivo results using a sarcoma mouse model showed observable antitumor action.

Oriģinālvaloda	Angļu
Lapas (no-līdz)	1428-1432
Lapu skaits	5
Žurnāls	Journal of Magnetism and Magnetic Materials
Sējums	321
Izdevuma numurs	10
DOIs	https://doi.org/10.1016/j.jmmm.2009.02.060
Publikācijas statuss	Publicēts - maijs 2009

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title = "Water-soluble magnetic nanoparticles with biologically active stabilizers",

abstract = "We present the results of the interaction of iron oxide nanoparticles with some biologically active surfactants, namely, oleic acid and cytotoxic alkanolamine derivatives. Physico-chemical properties, as magnetization, magnetite concentration and particle diameter, of the prepared magnetic samples were studied. The nanoparticle size of 11 nm for toluene magnetic fluid determined by TEM is in good agreement with the data obtained by the method of magnetogranulometry. In vitro cytotoxic effect of water-soluble nanoparticles with different iron oxide:oleic acid molar ratio were revealed against human fibrosarcoma and mouse hepatoma cells. In vivo results using a sarcoma mouse model showed observable antitumor action.",

keywords = "Antitumor activity, Cytotoxicity, Iron oxide, Magnetic nanoparticle, Oleic acid",

author = "Alla Zablotskaya and Izolda Segal and Edmunds Lukevics and Mikhail Maiorov and Dmitry Zablotsky and Elmars Blums and Irina Shestakova and Ilona Domracheva",

year = "2009",

month = may,

doi = "10.1016/j.jmmm.2009.02.060",

language = "English",

volume = "321",

pages = "1428--1432",

journal = "Journal of Magnetism and Magnetic Materials",

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TY - JOUR

T1 - Water-soluble magnetic nanoparticles with biologically active stabilizers

AU - Zablotskaya, Alla

AU - Segal, Izolda

AU - Lukevics, Edmunds

AU - Maiorov, Mikhail

AU - Zablotsky, Dmitry

AU - Blums, Elmars

AU - Shestakova, Irina

AU - Domracheva, Ilona

PY - 2009/5

Y1 - 2009/5

N2 - We present the results of the interaction of iron oxide nanoparticles with some biologically active surfactants, namely, oleic acid and cytotoxic alkanolamine derivatives. Physico-chemical properties, as magnetization, magnetite concentration and particle diameter, of the prepared magnetic samples were studied. The nanoparticle size of 11 nm for toluene magnetic fluid determined by TEM is in good agreement with the data obtained by the method of magnetogranulometry. In vitro cytotoxic effect of water-soluble nanoparticles with different iron oxide:oleic acid molar ratio were revealed against human fibrosarcoma and mouse hepatoma cells. In vivo results using a sarcoma mouse model showed observable antitumor action.

AB - We present the results of the interaction of iron oxide nanoparticles with some biologically active surfactants, namely, oleic acid and cytotoxic alkanolamine derivatives. Physico-chemical properties, as magnetization, magnetite concentration and particle diameter, of the prepared magnetic samples were studied. The nanoparticle size of 11 nm for toluene magnetic fluid determined by TEM is in good agreement with the data obtained by the method of magnetogranulometry. In vitro cytotoxic effect of water-soluble nanoparticles with different iron oxide:oleic acid molar ratio were revealed against human fibrosarcoma and mouse hepatoma cells. In vivo results using a sarcoma mouse model showed observable antitumor action.

KW - Antitumor activity

KW - Cytotoxicity

KW - Iron oxide

KW - Magnetic nanoparticle

KW - Oleic acid

UR - https://www.scopus.com/pages/publications/64549144184

U2 - 10.1016/j.jmmm.2009.02.060

DO - 10.1016/j.jmmm.2009.02.060

M3 - Article

AN - SCOPUS:64549144184

SN - 0304-8853

VL - 321

SP - 1428

EP - 1432

JO - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

IS - 10

ER -

Water-soluble magnetic nanoparticles with biologically active stabilizers

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