X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors

Jekaterina Ivanova; Janis Leitans; Muhammet Tanc; Andris Kazaks; Raivis Zalubovskis; Claudiu T. Supuran; Kaspars Tars

doi:10.1039/c5cc01854d

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors

Jekaterina Ivanova
, Janis Leitans
, Muhammet Tanc
, Andris Kazaks
, Raivis Zalubovskis^*
, Claudiu T. Supuran
, Kaspars Tars

^*Šī darba korespondējošais autors

Molekulāro dzīvības zinātņu, mikrobioloģijas un biotehnoloģijas nodaļa

Latvian Institute of Organic Synthesis
Latvian Biomedical Research and Study Centre
University of Florence

Zinātniskās darbības rezultāts: Devums žurnālam › Zinātniskais raksts (žurnālā) › koleģiāli recenzēts

77 Atsauces (Scopus)

Kopsavilkums

1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications.

Oriģinālvaloda	Angļu
Lapas (no-līdz)	7108-7111
Lapu skaits	4
Žurnāls	Chemical Communications
Sējums	51
Izdevuma numurs	33
DOIs	https://doi.org/10.1039/c5cc01854d https://doi.org/10.1039/C5CC01854D
Publikācijas statuss	Publicēts - 28 apr. 2015

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abstract = "1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications.",

author = "Jekaterina Ivanova and Janis Leitans and Muhammet Tanc and Andris Kazaks and Raivis Zalubovskis and Supuran, \{Claudiu T.\} and Kaspars Tars",

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doi = "10.1039/c5cc01854d",

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T1 - X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors

AU - Ivanova, Jekaterina

AU - Leitans, Janis

AU - Tanc, Muhammet

AU - Kazaks, Andris

AU - Zalubovskis, Raivis

AU - Supuran, Claudiu T.

AU - Tars, Kaspars

PY - 2015/4/28

Y1 - 2015/4/28

N2 - 1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications.

AB - 1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications.

UR - https://www.scopus.com/pages/publications/84927761732

U2 - 10.1039/c5cc01854d

DO - 10.1039/c5cc01854d

M3 - Article

C2 - 25813715

AN - SCOPUS:84927761732

SN - 1359-7345

VL - 51

SP - 7108

EP - 7111

JO - Chemical Communications

JF - Chemical Communications

IS - 33

ER -

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors

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